Sintesis Senyawa Turunan Amoksilin Dan Uji Aktivitas Antibakterinya Terhadap Bakteri Salmonella typhi

  • Hadi Barru Hakam Fajar Siddiq Akademi Farmasi Jember
  • Dewi Rashati Akademi Farmasi Jember
  • Dewi Riskha Nurmalasari Akademi Farmasi Jember

Abstract

The synthesis of amoxicillin derivate has been done by reacting amoxicillin with 4-t-butylbenzoil chloride. The product was characterized by organoleptic test, melting point determination, TLC, UV/Vis Spectrophotometry, and FTIR Spectrophotometry. Antibacterial activity of amoxicillin derivative against Salmonella typhi were tested using dilution method. Result showed that the product has characteristic as follow: light yellow powder, bitter bite, melting point of 132 °C, Rf value of 0.86, pH value of 7.7, maximum wavelength (uv) of 286 nm. Moreover, FTIR spectra of amoxicillin derivate exhibited peaks at 3271 cm-1 (-NH amine), 2962 cm-1 (-CH aromatic), 1633 cm-1 (-C=O ketone), and other. Antibacterial test showed that amoxicillin derivate was unable to form a clear zone around the disc paper. Amoxicillin derivate cannot be used for the treatment of Salmonella typhi.

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Published
2019-01-17
How to Cite
SIDDIQ, Hadi Barru Hakam Fajar; RASHATI, Dewi; NURMALASARI, Dewi Riskha. Sintesis Senyawa Turunan Amoksilin Dan Uji Aktivitas Antibakterinya Terhadap Bakteri Salmonella typhi. Media Pharmaceutica Indonesiana (MPI), [S.l.], v. 2, n. 2, p. 90-97, jan. 2019. ISSN 2527-9017. Available at: <http://journal.ubaya.ac.id/index.php/MPI/article/view/1319>. Date accessed: 22 apr. 2019. doi: https://doi.org/10.24123/mpi.v2i2.1319.
Section
Original Research Articles