MPI (Media Pharmaceutica Indonesiana)

Faktor - Faktor yang Mempengaruhi Ketidaksesuaian Pemberian Statin pada First-user Statins di Apotek UBAYA

2023-06-30T14:19:08+00:00

Penyakit kardiovaskular adalah salah satu penyebab kematian terbesar, baik di Indonesia dan di dunia. Statin telah terbukti efektif untuk pencegahan primer dan sekunder penyakit kardiovaskular. Akan tetapi, beberapa penelitian menunjukkan penggunaan statin untuk indikasi tersebut masih belum optimal. Tujuan penelitian ini adalah untuk mengidentifikasi factor-faktor yang mempengahruhi ketidaksesuaian penggunaan statin pada pengguna statin pertama kali (first-user). Penelitian ini adalah penelitian retrospektif yang melibatkan 102 orang pasien yang berkunjung ke Apotek UBAYA. Hasil penelitian menunjukkan bahwa 56,9% pasien yang terlibat adalah perempuan dan 42,2% pasien berada pada kelompok usia 51-60 tahun. Berdasarkan perhitungan tingkat risiko kardiovaskular 10-tahun, sebesar 24.5% pasien mengalami ketidaksesuaian penggunaan statin. Ketidaksesuaian penggunaan statin ini khususnya ditemukan pada kelompok risiko tinggi (51,7%) dan kelompok risiko sangat tinggi (23,7%). Faktor-faktor yang mempengaruhi ketidaksesuaian penggunaan statin adalah memiliki diabetes mellitus (adjusted odds ratio, aOR 10,61; 95% CI 2,84-39,68; p = 0,00) dan memiliki asuransi kesehatan (aOR 4,96; 95% CI 1,49-16,48; p = 0,01).

Cardiovascular disease (CVD) is one of the leading causes of deaths both in Indonesia and in the world. Statins have been proven to be effective for primary and secondary prevention of CVDs. However, several studies show that the use of statins for those indications are still sub optimal. The aimof this study was to identify factors influencing inappropriateness use of statins in the first-user statins. This was a retrospective study involving 102 patients visited the UBAYA Pharmacy. The result of the study showed that 56.9% of the patients involved were women and 42.2% of the patients were in the age group of 51-60 years. Based on the 10-year cardiovascular risk estimation, as many as 24.5% of the patients inappropriately used statins. The inappropriateness use of statins was especially found in the high-risk group (51.7%) and in the very high-risk group (23.7%). Factors influencing the inappropriateness use of statins in the first-user statins were having diabetes mellitus (adjusted odds ratio, aOR 10.61; 95% CI 2.84-39.68; p = 0.00) and having health insurance (aOR 4.96; 95% CI 1.49-16.48; p = 0.01).

Kajian Continuity of Care Pasien Program Rujuk Balik di Puskesmas Kota Surabaya

2023-06-30T14:18:49+00:00

Pasien penyakit kronis menjalani transisi pelayanan kesehatan, sehingga kesinambungan perawatan atau continuity of care (CoC) menjadi komitmen antar tenaga kesehatan. CoC diukur dari perspektif pasien berdasarkan pengalaman dalam pelayanan kesehatan terkait kesinambungan informasi, hubungan dan manajerial. Tujuan penelitian adalah melakukan kajian CoC pasien DM tipe 2 dan hipertensi PRB Puskesmas Kota Surabaya dan menggali pengalaman pasien dalam transisi pelayanan kesehatan. Rancangan penelitian adalah mixed methods. Sampel ditentukan secara purposive dengan memperhatikan kriteria penelitian. Pengumpulan data dilakukan dengan menggunakan kuesioner Cuestionario Continuidad Asistencial Entre Niveles de Atencion (CCAENA) dan wawancara semi-terstruktur. Kesinambungan hubungan berada pada tingkat yang tertinggi, dimana hubungan dengan dokter spesialis lebih tinggi (95%) dibandingkan dokter umum (74%). Ketidaksinambungan hubungan terbesar, yaitu tidak bisa berkonsultasi dengan dokter yang sama di Puskesmas (58%). Kesinambungan manajerial terkait koherensi perawatan (91%) dan aksesibilitas (79%). Ketidaksinambungan manajerial terbesar adalah tidak ada koherensi perawatan antara dokter spesialis dan dokter di Puskesmas (85%) serta aksesibilitas saat antri di rumah rakit (48%). Kesinambungan informasi berada pada tingkat paling rendah (73%). Ketidaksinambungan informasi terbesar adalah diskusi antara pasien dan dokter di Puskesmas terkait pengobatan setelah rujukan (37%). Kesimpulan dari penelitian ini adalah ketidaksinambungan dalam transisi perawatan pasien penyakit kronis terbesar adalah pemberian informasi. Apoteker memiliki peran penting untuk meningkatkan pelayanan informasi dan menjamin keselamatan pasien disetiap rantai perawatan.

Transition of healthcare increases the risk of chronic disease patients, therefore continuity of care (CoC) is needed for patient care. CoC measure from the patient's perspective based on experience related to continuity of information, relationships and managerial. The purpose was to study of CoC patients with type 2 diabetes mellitus (T2DM) and hypertension referral program at the Surabaya City Public Health Center and explore patient experiences in transitioning health services. The design is mixed methods. The sample was determined purposively by observe into research criteria. Data collection was using the Cuestionario Continuidad Asistencial Entre Niveles de Atencion (CCAENA) questionnaire and semi-structured interviews. Relation continuity is the highest level, where relationships with specialist are higher (95%) than general prescriber (GP) (74%). The biggest discontinuity is not being able to consult the same GP (58%). Managerial continuity related to coherence of care (91%) and accessibility (79%). The biggest managerial discontinuity is coherence between specialist and GP (85%) and accessibility when queuing at the hospital (48%). Information continuity is the lowest level (73%). The biggest discontinuity is discussion between patients and GP regarding treatment after referral (37%). Conclusion this study is the biggest discontinuity in the transition of care for chronic disease patients is information. Pharmacists have an important role to improve information services and ensure patient safety.

The Impact of Pharmaceutical Care Implementation on The Incidence of Drug-Related Problem and Clinical Outcome of Hypertension Patients at Puskesmas Lubuk Pakam in 2021

2023-06-30T14:18:28+00:00

The role of pharmacists in the implementation of pharmaceutical care has been shown to improve the outcome of therapy in hypertension patients in various countries. This study aimed to implement pharmaceutical care for hypertension patients and determine its impact on the incidence of drug-related problems (DRPs) and clinical outcomes of hypertension patients in Puskesmas Lubuk Pakam. This study used a comparative experimental method before and after the intervention of 73 hypertension patients in March-August 2021. Identification of the of DRPs was using the PCNE V9.00 standard and blood pressure values were obtained from direct examination of patients. Data were analyzed using the Wilcoxon Signed-Rank test. The results showed that the average DRPs incidence was significantly reduced after the intervention (observation, interview, and education) on the hypertension patients. The average blood pressure before intervention was 154.38 ± 16.20 mmHg and after intervention became 144.04 ± 15.94 mmHg (p value = 0.000). Based on the results of the study, it can be concluded that the application of pharmaceutical care can reduce the incidence of DRPs and improve clinical outcomes in hypertension patients in Puskesmas Lubuk Pakam.

The Efficacy of Watermelon (Citrullus lanatus) Rind Extract in Healing Burns in Balb/C Male Mice

2023-06-30T14:18:10+00:00

Burns are skin tissue damage that occurs as a result of direct contact with a heat source. One of the natural treatments for burns is watermelon (Citrullus lanatus) rind. Watermelon rind contains citrulline, an alkaloid that plays a role in wound healing. This study aims to explore the potential of watermelon rind to become extract gel as a burn remover in male Balb/C strain mice. This research method is a true experiment that begins with the preparation of watermelon rind extract by maceration with ethanol. Furthermore, the polyphenol, flavonoid, saponin, and alkaloid content of the extract was identified through the phytochemical screening. The next stage was the preparation of a gel with three variations of extract concentrations, namely 25%, 50%, and 75% w/v. The gels were characterized by organoleptic, pH, and spreadability. The final stage tested the gel’s activity as a burn wound healing in male Balb/C strain mice. The results showed that the extract contained saponins, polyphenols, flavonoids, and alkaloids. The spreadability test results of the gel showed that all gels met the requirements. All gels had activity against burns in male Balb/C strain mice. Thus, watermelon rind extract can be used as a medicine for burns.

Anatomi Jaringan, Identifikasi Mikroskopis, serta Kadar Polifenol Ekstrak Etanol Daun dari Tiga Jenis Jambu Genus Syzygium

2023-06-30T14:17:49+00:00

Tiga spesies dari genus Syzygium, seperti jambu air (Syzygium aqueum (Burm.f.) Alston), jambu bol (Syzygium malaccense (L.) Merr. & L.M. Perry), dan jambu semarang (Syzygium samarangense (Blume) Merr. & L. M. Perry), telah dimanfaatkan daunnya dalam pengobatan tradisional karena kandungan polifenolnya. Penelitian ini bertujuan untuk mempelajari anatomi jaringan, mikroskopis, kadar senyawa fenol, flavonoid, dan tanin ekstrak etanol daun dari tiga jenis jambu tersebut. Daun jambu biji (Psidium guajava) digunakan sebagai pembanding. Anatomi jaringan daun dan identifikasi mikroskopis dilakukan menggunakan mikroskop. Penentuan kadar senyawa pada ekstrak etanol 70% ditentukan dengan metode kolorimetri yang absorbansinya diukur pada spektrofotometer UV- Vis. Anatomi jaringan daun dan fragmen pengenal secara mikroskopis ada kemiripan pada ketiga jenis daun jambu genus Syzygium. Secara statistik, ada perbedaan signifikan antara kadar fenol, flavonoid, dan tanin pada ekstrak etanol 70% daun jambu air, daun jambu bol, dan daun jambu semarang dibandingkan dengan ekstrak etanol 70% daun jambu biji. Daun jambu air merupakan spesiesterpilih dari genus Syzygium yang diuji pada penelitian ini dengan kandungan polifenol yang tinggi.

Leaves of three guava species of the genus Syzygium, such as water apple/jambu air (Syzygium aqueum (Burm.f.) Alston), malay apple/jambu bol (Syzygium malaccense (L.) Merr. & L.M. Perry), and wax apple/jambu Semarang (Syzygium samarangense (Blume) Merr. & L. M. Perry), have been used in traditional medicine because of its polyphenol content. This study aims to investigate the anatomy of leaf tissues, powder microscopical characteristic, and total phenolic, flavonoids, and tannins content in the ethanol extract of the leaves of the three types of selected guava species of the genus Syzygium. Guava leaves (Psidium guajava) were used as a comparison. Leaf tissue anatomy and microscopic identification were carried out using a microscope. Determination of the polyphenol content in 70% ethanol extract was determined by the colorimetric method in which the absorbance was measured on a UV-Vis spectrophotometer. Leaf tissue anatomy and microscopic recognition fragments are similar in the three types of Syzygium guava leaves. Statistically, there were significant differences between the total phenols, flavonoids, and tannins content in the 70% ethanol extract of water apple, Malay apple, and wax apple compared to the 70% ethanol extract of guava leaves. Water apple leaves are selectedspecies from the genus Syzygium tested in this study with high polyphenol content.

Pengaruh Variasi Konsentrasi Dinatrium EDTA Terhadap Stabilitas Fisika dan pH Sediaan Salep Ekstrak Etanol Daun Jambu Biji (Psidium guajava L.)

2023-06-30T14:17:30+00:00

Daun jambu biji (Psidium guajava L.) merupakan salah satu tanaman yang berkhasiat, karena mengandung metabolit sekunder saponin, tanin, flavonoid, serta alkaloid. Senyawa-senyawa tersebut memiliki sifat antibakteri. Kandungan antibakteri pada daun jambu biji ini menjadi dasarpengembangan sediaan dalam bentuk salep yang berkhasiat sebagai antibakteri dengan memvariasikan salah satu bahan sebagai penstabil yaitu dinatrium EDTA. Tujuan dari penelitian ini adalah mengetahui pengaruh konsentrasi dinatrium EDTA tehadap stabilitas fisika sediaan salep ekstraketanol daun jambu biji (Psidium guajva L.). Dalam penelitian ini dibuat 3 formula dengan variasi konsentrasi dinatrium EDTA yaitu F1 (0,05%); F2 (0,08%) serta F3 (0,10%). Evaluasi stabilitas fisik sediaan salep dilakukan selama 12 hari (6 siklus), meliputi uji organoleptik, uji homogenitas, uji pH, uji daya lekat, uji daya sebar dan uji stabilitas. Hasil pengamatan organoleptik selama cycling test menunjukan adanya perubahan warna pada sediaan yaitu pada siklus ke 5 dan 6. Selain itu, dengan bertambahnya konsentrasi dinatrium EDTA berpengaruh terhadap pH. Semakin tinggi konsentrasi dinatrium EDTA maka semakin kecil pH dan berpengaruh pada stabilitas fisika sediaan. Hasil menunjukan bahwa sediaan yang stabil dan memenuhi syarat yaitu formula 3 dengan konsentrasi dinatrium EDTA 0,10 %.

Guava leaves (Psidium guajava L.) is one of the efficacious plants, because it contains secondary metabolites of saponins, tannins, flavonoids, and alkaloids; where these compounds have antibacterial properties. With the presence of antibacterial content in guava leaves, a preparation was made in the form of an antibacterial ointment by varying one of the ingredients as a stabilizer, namely disodium EDTA. The purpose of this study was to determine the effect of disodium EDTA concentration on the physical stability of the ethanol extract ointment of guava leaves (Psidium guajva L.). In this study, 3 formulas were prepared with variations in the concentration of disodium EDTA, namely F1 (0.05%); F2 (0.08%) and F3 (0.10%), respectively. Evaluation of the physical stability of the ointment was carried out for 12 days (6 cycles), including organoleptic tests, homogeneity tests, pH tests, adhesion tests, spreadability tests and stability tests. The results of organoleptic observations during the cycling test showed that there was a change in the color of the preparation in the 5th and 6th cycles. In addition, increasing the disodium EDTA concentration affected the pH, where the higher the disodium EDTA concentration, the lower the pH and affected the physical stability of the preparation. The results showed that the preparation that met the requirements for ointment stability was formula 3 with a concentration of 0.10% disodium EDTA.

Aktivitas Antiansietas Ekstrak Etanol Kulit Buah Pisang Cavendish (Musa acuminata Cavendish): Studi In Vivo dengan Metode Elevated Plus Maze (EPM), Light Dark Test (LDT), and Open Field Test (OFT)

2023-06-30T14:17:11+00:00

Gangguan kecemasan (ansietas) adalah kondisi medis yang dikarakterisasi oleh adanya perasaan cemas akan sesuatu yang bersifat irasional. Beberapa gangguan kecemasan yang umum terjadi adalah gangguan kecemasan tergeneralisasi, gangguan panik, fobia, gangguan kecemasan social, dan post-traumatic stress disorder (PTSD). Kulit pisang Cavendish (Musa acuminata Cavendish) mengandung berbagai senyawa bioaktif, seperti flavonoid gatokatekin yang diduga memiliki sifat antiansietas. Penelitian ini bertujuan untuk mengetahui efek antiansietas ekstrak etanol kulit pisang Cavendish (Musa acuminata Cavendish) dengan berbagai dosis. Penelitian eksperimen dilakukan dengan post-test only control group design. Tiga puluh mencit putih Swiss Webster (Mus musculus) jantan dibagi menjadi 5 kelompok secara acak: kelompok kontrol (CMC Na 1%), kelompok obat standar (diazepam 0,13 mg/kgBB), dan tiga kelompok ekstrak kulit pisang Cavendish (EEKPC) dengan dosis 200 mg/kg, 400 mg/kg dan 800 mg/kg. Aktivitas antiansietas dievaluasi dengan Elevated plus maze (EPM), light dark test (LDT), dan open field test (OFT). Hasil penelitian menunjukkan bahwa EEKPC 200 mg/kg secara signifikan meningkatkan durasi hewan uji di tangan terbuka pada uji EPM (p<0,05) dibandingkan dengan kelompok kontrol. Dosis EEKPC 200 mg/ kg juga mampu meningkatkan durasi di area terang secara signifikan pada uji LDT dibandingkan dengan kelompok kontrol (p<0,05). Pada OFT, dosis EKPC 200 mg/kg secara signifikan meningkatkan durasi di area tengah (p<0,05) dibandingkan dengan kelompok kontrol. Hasil penelitian ini mendukung pengembangan kulit pisang Cavendish (Musa acuminata Cavendish) sebagai terapi komplementer untuk gangguan kecemasan.

Anxiety disorder is a mental health condition characterized by feelings of anxiety and irrational fear of something. These disorders include generalized anxiety disorder, panic disorder, phobias, social anxiety disorder, and post-traumatic stress disorder. Cavendish banana peel (Musa acuminata Cavendish) contains various bioactive compounds, including flavonoid galocatechin which is proposed to have antianxiety properties. This study was aimed to determine the antianxiety effect of various doses of 80% ethanolic extract of Cavendish banana peel (Musa acuminata Cavendish). The experimental study was conducted with a post-test only control group design. Thirty male Swiss Webster white mice (Mus musculus) were divided randomly into 5 groups: control group (CMC Na 1%), the standard drug group (diazepam 0.13 mg/kgBW), and three groups of Cavendish banana peel extract (EEKPC) at doses of 200 mg/kg, 400 mg/kg and 800 mg/kg. Antianxiety activity was evaluated by elevated plus maze (EPM), light dark test (LDT), and open field test (OFT). The results showed that EEKPC 200 mg/kg significantly increased the duration of the test animals in the open arms in the EPM test (p<0.05) compared to the control group. EEKPC dose of 200 mg/kg was also able to significantly increase the duration in the light area in the LDT test compared to the control group (p<0.05). In OFT, EKPC dose of 200 mg/kg significantly increased duration in the center area (p<0.05) compared to control group. Results of this study supports the development of Cavendish banana peel (Musa acuminata Cavendish) as a complementary therapy for anxiety disorder.

Mekanisme Penghambat Sodium-Glukosa Transport Protein-2 (SGLT2-i) pada Penyakit Kardiovaskular: Sebuah Tinjauan

2023-06-30T14:16:52+00:00

Proteksi kardiovaskular penting sebagai salah satu target tatalaksana pasien diabetes mellitus (DM) tipe 2. Penghambat sodium-glukosa kotransporter 2 (SGLT2-i), obat antidiabetik relatif baru yang bekerja dengan cara memblokade transporter SGLT-2 di tubulus proksimal ginjal, diketahui memiliki fungsi proteksi kardiovaskular yang baik. Uji klinis CANVAS, EMPA-REG, DECLARE-TIMI 58, VERTIS-CV masing-masing menggunakan kanagliflozin, empagliflozin, dapagliflozin, dan ertugliflozin menunjukkan superioritas atau setara dengan plasebo. Penulisan studi literatur ini menggunakan telaah jurnal-jurnal penelitian menggunakan PubMed, SAGE, dan Google Scholar. Tujuan tinjauan ini adalah untuk merangkum konsep terkini mekanisme protektif SGLT2-i pada kejadian kardiovaskular dan penggunaannya pada pasien jantung dengan atau tanpa diabetes mellitus. SGLT2-i ditemukan menurunkan risiko hospitalisasi akibat gagal jantung (30%) dan penyakit ginjal (45%) pada pasien DM tipe 2. SGLT2-i juga lebih terjangkau dan menurunkan biaya perawatan rumah sakit. Karena masih relatif baru, penelitian-penelitian yang ada masih berfokus pada luaran klinis, mortalitas dan keamanan obat ini. Mekanisme kerja efek proteksi kardiovaskular obat ini kebanyakan masih berdasarkan uji preklinis. SGLT2-i memiliki banyak efek farmakologis yang terbukti bermanfaat dalam mencegah penyakit kardiovaskular terutama gagal jantung. Uji klinis menunjukkan manfaat kardioprotektif SGLT2-i bukan berasal dari efek antiglikemiknya, namun melalui mekanisme kompleks yang berhubungan dengan volume dan diuresis, penurunan beban jantung, metabolisme jantung, serta proteksi vaskular.

Cardiovascular protection is one of the treatment targets for type 2 DM patients. Sodium- glucose cotransporter 2 inhibitor (SGLT2-i), a relatively new antidiabetic drug that works by blocking the SGLT-2 transporter in the proximal renal tubule, is not expected to have a cardiovascular protectivefunction. CANVAS, EMPA-REG, DECLARE-TIMI 58, VERTIS-CV clinical evaluation using kanagliflozin, empagliflozin, dapagliflozin, and ertugliflozin showed the superiority or equal to the placebo. This literature study uses a review of research journals using PubMed, SAGE, and Google Scholar. This review aims to summarize the current concept of the protective mechanism of SGLT2-i in cardiovascular events and its use in cardiac patients with or without diabetes mellitus. SGLT2-i was found to reduce the risk of hospitalization due to heart failure (30%) and kidney disease (45%) in type 2 DM patients. SGLT2-i is also more affordable and lowers hospitalization costs. Because it is still relatively new, the existingstudies still focus on clinical outcomes, mortality, and safety of this drug. The mechanism of action for cardiovascular protection is mostly based on preclinical trials. SGLT2-i has many pharmacological effects that have proven beneficial in preventing cardiovascular disease, especially heart failure. Clinical trials have shown that the cardioprotective benefits of SGLT2-i are not derived from its anti-glycemic effect, but through complex mechanisms related to volume and diuresis, decreased cardiac load, cardiac metabolism, and vascular protection.

Pola Penggunaan Obat pada Disabilitas Tunanetra: Kajian Naratif

2023-06-30T14:16:33+00:00

Penggunaan obat merupakan salah satu kesulitan yang dialami oleh disabilitas tunanetra dalam meningkatkan kualitas kesehatannya. Tujuan penulisan artikel ini adalah untuk mengetahui pola penggunaan obat di kalangan penyandang disabilitas tunanetra. Metode yang digunakan dalam penulisan artikel ini adalah literature review. Pencarian artikel dilakukan melalui Google Scholar dan PubMed dengan kata kunci berupa medication problems, drug use, dan visual impairments. Jumlah artikel yang berhasil dikumpulkan sebanyak 292 artikel, namun hanya empat artikel yang termasuk dalam kriteria inklusi. Hasil penelitian menunjukkan bahwa terdapat dua pola penggunaan obat utama yang digunakan oleh disabilitas tunanetra, yaitu mengandalkan bantuan orang lain dengan penglihatan normal dan menerima obat sendiri. Kedua pola ini memberikan bentuk bantuan yang berbeda bagi disabilitas tunanetra untuk dapat menggunakan obat dengan cara yang benar.

The use of drugs is one of the difficulties experienced by the visually impaired in improving the quality of their health. The purpose of this review article is to find out the pattern of drug use among blind people with disabilities. The method used in writing this article is a literature review. Article searches were conducted through Google Scholar and PubMed with keywords such as medication problems, drug use, and visual impairments. The total number of articles found was 292, but only four articles met the inclusion criteria. The results showed that there were two main patterns of drug use for blind people, namely, relying on the help of others with normal vision and receiving the drug itself. These two patterns provide different forms of assistance for the visually impaired to use drugs in the right way.

Kajian Pustaka: Sediaan Kosmesetika Penumbuh Rambut dari Berbagai Herbal Nusantara

2023-06-30T14:16:11+00:00

Kerontokan rambut dapat menjadi permasalahan serius ketika dalam jumlah yang abnormal dan terjadi secara terus-menerus hingga berujung kebotakan. Kosmesetika penumbuh rambut berbahan dasar herbal dapat menjadi pilihan terapi yang tepat sebab terkait dengan keamanan penggunaan jangka panjang maupun efektivitasnya. Berbagai bentuk sediaan kosmesetika herbal penumbuh rambut telah dikembangkan yakni emulsi, gel, emulgel, krim, serum, hair tonic maupun sediaan yang dimodifikasi dengan sistem teknologi nano. Artikel review ini bertujuan untuk mengetahui sediaan kosmesetika herbal terbaik yang memenuhi spesifikasi farmasetik yang telah ditetapkan dan aktivitasnya sebagai penumbuh rambut secara in vivo. Penelitian ini berbasis systematic literature review. Berdasarkan eksplorasi literatur yang telah dilakukan dapat diketahui bahwa sediaan kosmesetika herbal terbaik dalam meningkatkan pertumbuhan rambut dan memenuhi kriteria karakteristik farmasetik adalah adalah sediaan hair tonic daun kangkung (Ipomoea aquatica Forsk.) (5%) dengan rerata peningkatan panjang rambut sebesar (2,785 ± 0,021 cm) dan bobot rambut (0,767 ± 0,057 mg/cm2) selama 21 hari. Evaluasi farmasetik hair tonic daun kangkung telah memenuhi persyaratan SNI sediaan hair tonic yang telah ditetapkan.

Hair loss can be a serious problem when it is in abnormal amounts and occurs continuously leading to baldness. Herbal-based hair growth cosmeceuticals can be the right choice of therapy because it is related to the safety of long-term use and its effectiveness. Various dosage forms of herbal hair growth cosmeceuticals have been developed, namely emulsions, gels, emulgels, creams, serums, hair tonic and preparations modified with nano technology systems. This review article aims to determine the best herbal cosmeceutical preparations that meet the established pharmaceutical specifications and their activity as hair growth in vivo. This research is based on systematic literature review. Based on the literature exploration that has been carried out, it can be seen that the best herbal cosmeceutical preparation in increasing hair growth and meeting the criteria for pharmaceutical characteristics is the preparation of kale leaf hair tonic (Ipomoea aquatica Forsk.) (5%) with an average increase in hair length of (2.785 ± 0.021 cm) and hair weight (0.767 ± 0.057 mg/cm2) in 21 days. Pharmaceutical evaluation of kale leaf hair tonic has met the requirements of SNI hair tonic preparations that have been established.