PENGARUH PERBEDAAN KONSENTRASI SURFAKTAN TERHADAP KARAKTER FISIK DAN pH NANOEMULSI PENCERAH KULIT
Abstract Views:
1419 times
PDF - FULL TEXT Downloads:
4768 times
Abstract
Bahan aktif yang digunakan untuk kosmetik pencerah kulit salah satunya adalah vitamin E asetat dan minyak dedak karena mempunyai aktifitas antioksidan yang tinggi. Untuk meningkatkan penetrasi bahan aktif tersebut, dibuat dalam bentuk nanoemulsi. Salah satu komponen yang paling penting pada nanoemulsi adalah surfaktan. Penelitian ini dilakukan untuk mengetahui pengaruh konsentrasi surfaktan terhadap karakter fisik berat jenis, viskositas, sifat alir, persen transmitan, ukuran droplet dan pH nanoemulsi pencerah kulit. Pada penelitian ini mennggunakan PEG-40 Hydrogenated Castor Oil sebagai surfaktan dan sorbitan monooleat sebagai co-surfaktan, dengan HLB 11,3. Formula 1,2,3 menggunakan surfaktan dan co-surfaktan secara berurutan 15%, 10%, 5%. Pembuatan nanoemulsi dilakukan dengan metode energi tinggi dengan alat highshear stirring. Hasil penelitian ini menunjukkan dari ketiga formula F1, F2 dan F3 tidak ada perbedaan karakter fisik berat jenis, viskositas, sifat alir dan pH. Tetapi ada perbedaan karakter persen transmitan dan ukuran droplet. Hanya formula 1 yang menghasilkan ukuran droplet yang memenuhi syarat nanoemulsi yaitu 53,53 ± 1,14 nm.
Downloads
References
Ali SA, Choudhary RK, Naaz I, et al, 2015, Understanding the Challenges of Melanogenesis: Key Role of Bioactive Compounds in the Treatment of Hyperpigmentory Disorders, Journal of Pigmentary Disorders, 2:11
Aulton ME, Taylor KMG, 2013, Aulton’s Pharmaceutics: The Design and Manufacture of medicines, 4th ed, Elsevier, Toronto
Bernardi DS, Pereira TA, Maciel NR, et al, 2011, Formation and stability of oilin-water nanoemulsion containing rice bran oil: in vitro and in vivo assessments, Journal of Nanobiotechnology, 9:44
Bopitiya D, Madhujith T, 2014, Antioxidant Potential of Rice Bran Oil Prepared from Red and White Rice, Tropical Agricultural Research Vol. 26 (1): 1-11
Chellapa P, Mohamed AT, Keleb EI, et el, 2015, Nanoemulsion and Nanoemulgel as a Topical Formulation, IOSR Journal of Pharmacy Vol 5, Issue 10
Departemen Kesehatan RI, 2013, Farmakope Indonesia Edisi V, Jakarta
Gupta PK, Pandit JK, Kumar A, et al, 2010, Pharmaceutical nanotechnology novel and nanoemulsion - High energy emulsification preparation, evaluation and aplication, The Pharma Research, 3 ; 117-138
Hasani F, Pazeshki A, Hamishehkar H, 2015, Effect of Surfactant and Oil Type on Size Droplets of Betacarotene-Bearing Nanoemulsions, Int J Curr Microbiol App Sci, Vol 4, No 9, 146-155
Mason TG, Wilking JN, Chang CB, et al, 2006, Nanoemulsion: formation, structure and physical properties, J Phys: Condens Matter 18: 635-666
Pareira TA, Guerreiro CM, Maruno M, et al, 2016, Exotic Vegetable Oils for Cosmetic O/W Nanoemulsion: In Vivo Evaluation, MDPI Journal Molecules, 21:248
- Articles published in CALYPTRA are licensed under a Creative Commons Attribution-ShareAlike 4.0 International license. You are free to copy, transform, or redistribute articles for any lawful purpose in any medium, provided you give appropriate credit to the original author(s) and the journal, link to the license, indicate if changes were made, and redistribute any derivative work under the same license.
- Copyright on articles is retained by the respective author(s), without restrictions. A non-exclusive license is granted to CALYPTRA to publish the article and identify itself as its original publisher, along with the commercial right to include the article in a hardcopy issue for sale to libraries and individuals.
- By publishing in CALYPTRA, authors grant any third party the right to use their article to the extent provided by the Creative Commons Attribution-ShareAlike 4.0 International license.
