FORMULASI DISPERSI PADAT DENGAN PERBANDINGAN KOMPOSISI PARASETAMOL DAN PEG 4000 (1:0,5DAN1:1)MENGGUNAKAN METODE PELEBURAN

  • Jhon Leonaritua Manullang Fakultas Farmasi Universitas Surabaya
  • Nani Parfati Fakultas Farmasi Universitas Surabaya
  • Karina Citra Rani Fakultas Farmasi Universitas Surabaya
Abstract Views: 1453 times
PDF - FULL TEXT Downloads: 4299 times
Keywords: Paracetamol, PEG 4000, Solid dispersion, dissolution, FTIR

Abstract

Abstract - Paracetamol is one of drugs which has low solubility property in aqueous medium. This property will affect its bioavailability. Enhancement of solubility can be achieved by formulation of solid dispersion. Paracetamol is dispersed in PEG 4000 as hydrophilic carrier with melting method. To find the effect of the amount of PEG 4000 for the solubility enhancement, two formulas of solid dispersion are made with the ratio of 1:0.5 and 1:1. After the solid dispersion formed, this formula is characterized using FTIR to determine the interactions between paracetamol and PEG 4000 as a sign of formed solid dispersion. After characterization, the amount of paracetamol in the formulationwill be measured. Lastly, dissolution test is performed to find the increase in dissolution rate compared to pure paracetamol powder. Dissolution test profile observation shows that paracetamol and PEG 4000 solid dispersion formulas have lower dissolution rate compared to pure paracetamol. Beside that, the drug content test shows that the content of paracetamol in the dosage form doesn’t meet the quality requirement as established in the Indonesian Pharmacopeia.

Downloads

Download data is not yet available.

References

Liu J, Cao F, Zhang Can, et all, 2013, Use of Polymer Combinations in the Preparation of Solid Dispersions of a Thermally Unstable Drug by Hot-melt Extrusion, Acta Pharmaceutica Sinica B,3(4) 263-272

Patel BB, Patel JK, Chakraborty S, et all, 2015, Revealing Facts Behind Spray Dried Solid Dispersion Technology Used for Solubility Enhancement, Saudi Pharmaceutical Journal, 232: 352-365

Ditjen POM, 2014, Farmakope Indonesia Edisi 5.Departemen Kesehatan Republik Indonesia, Jakarta

Liu C, Desai KG, 2005, Characteristics of Rofecoxib-Polyethylene Glycol 4000 Solid Dispersions and Tablets Based on Solid Dispersions, Pharmaceutical Development and Technology, 10:467–477

Nikghalb LA, et all, 2012, Solid Dispersion: Methods and Polymers to Increase the Solubility of Poorly Soluble Drugs, Journal of Applied Pharmaceutical Science,2(10)170-175

Ditjen POM, 1979, Farmakope Indonesia Edisi 3. Departemen Kesehatan Republik Indonesia, Jakarta

Akiladevi D, Andiyan PS, Jebasaingh D, et all., 2010, Perparation and Evaluation of Paracetamol by Solid Dispersion Techinque, Internation Journal of Pharmacy and Pharmaceutical Sciences, 3(1): 188-191

Allen LV jr, Popovich NG, Ansel HC, 2011, Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems 9thed, Lipincott Williams & Wilkins, a Wolters Kluwer Business, Baltimore, 148-152

Cartensen TJ, Leeson LJ, 1974, Dissolution Technology, The Industrial Pharmacutical Technology Section of the Academy of Pharmaceutical Science, Washington D.C.

Sweetman SC, 2009, Martindale: The Complete Drug Reference, Pharmaceutical Press, London

Moffat AC, Jackson JV, Moss MS, et al., 1986, Clarke’s Isolation and Identification of Drugs 2ndedition,The Pharmaceutical Press,London, 849-850

Madni MA, Ahmad S, Khan MI, et all, 2014 FTIR Drug-Polymer Interaction Studies of Perindopril Erbumine, Journal-Chemical Society ofPakistan, 36(6): 1064-1070

Shameli K, Ahmad M, Jazayeri SD, et all 2012, Synthesis and Characterization of Polyethylene Glycol Mediated Silver Nanoparticles by the Green Method, International Journal of Molecular Sciences13: 6639-6650
Published
2020-10-30
Issue
Vol. 7 No. 2 (2019): Calyptra : Jurnal Ilmiah Mahasiswa Universitas Surabaya (Maret)
Section
Bidang Farmasi (F)

Creative Commons License

  • Articles published in CALYPTRA are licensed under a Creative Commons Attribution-ShareAlike 4.0 International license. You are free to copy, transform, or redistribute articles for any lawful purpose in any medium, provided you give appropriate credit to the original author(s) and the journal, link to the license, indicate if changes were made, and redistribute any derivative work under the same license.
  • Copyright on articles is retained by the respective author(s), without restrictions. A non-exclusive license is granted to CALYPTRA to publish the article and identify itself as its original publisher, along with the commercial right to include the article in a hardcopy issue for sale to libraries and individuals.
  • By publishing in CALYPTRA, authors grant any third party the right to use their article to the extent provided by the Creative Commons Attribution-ShareAlike 4.0 International license.