EFEK JUS BUAH JAMBU BIJI (Psidium guajava Linn.) TERHADAP TIKUS PUTIH JANTAN HIPERGLIKEMIK AKIBAT EFEK SAMPING HIDROKLOROTIAZID
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Keywords:
Jus buah jambu biji (Psidium guajava Linn.), Tikus putih jantan hiperglikemik, Hidroklorotiazid
Abstract
Hidroklorotiazid merupakan agen antihipertensi yang dapat menginduksi kondisi hiperglikemik. Pada penelitian ini dilakukan uji antihiperglikemik terhadap tikus putih jantan hiperglikemik akibat efek samping hidroklorotiazid menggunakan jus buah jambu biji (Psidium guajava Linn). Hewan coba diukur kadar glukosa darah puasa dan dibagi menjadi 3 kelompok, kelompok kontrol diberi hidroklorotiazid selama 14 hari kemudian pemberian hidroklorotiazid tetap dilanjutkan bersama aquadem selama 7 hari, kelompok uji I diberi jus buah jambu biji secara bersamaan dengan hidroklorotiazid selama 21 hari, dan kelompok uji II diberi hidroklorotiazid selama 14 hari kemudian hidroklorotiazid tetap dilanjutkan pemberiannya bersama dengan terapi jus buah jambu biji selama 7 hari. Hidroklorotiazid diberikan setiap hari dengan dosis 30 mg/kgBB 1 kali sehari. Jus buah jambu biji diberikan dengan dosis 1g/tikus (berat badan tikus ± 200 g) 1 kali sehari setiap hari. Semua pemberian dilakukan secara oral. Tiap kelompok diukur kadar glukosa darah puasa. Data yang diperoleh dianalisis dengan metode One-way Anova. Hasil yang didapat menunjukkan jus buah jambu biji lebih efektif memperbaiki kondisi hiperglikemik akibat efek samping hidroklorotiazid jika dikonsumsi dalam waktu yang bersamaan.
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British National Formulary (BNF 59th ed), 2010, Published by BMJ Published Group Ltd.
Brunton LL, 2006, Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 11th ed, The McGraw-Hill Companies,Inc., New York.
Departemen Farmakologi dan Terapeutik Fakultas Kedokteran Universitas Indonesia, 2007, Farmakologi dan Terapi, Gaya Baru, Jakarta.
Departemen Kesehatan Republik Indonesia, 1995, Farmakope Indonesia Edisi IV,
Departemen Kesehatan, Jakarta.
Departemen Kesehatan Republik Indonesia, 2007, Pedoman Pengobatan Dasar Di Puskesmas, (online), (http://depkes.go.id, diakses pada 13 Oktober 2012).
Dipiro JT, Robert LT, Gary CY, Gary RM, Barbara GW, Posey LM, 2008, Pharmacotherapy a Pathophysiologic Approach, 7th ed, The McGraw-Hill Companies,Inc., New York, 1205.
European Heart Journal, 2007, Guidelines for The Management of Arterial Hypertension, (Online), (http://www.escardio.org, diakses pada 27 Agustus 2012 ), 1493-1494.
Francisca Nancy, 2011, Efek Jus Buah Jambu Biji (Psidium guajava Linn) Terhadap Berat Badan Penderita Obesitas, Skripsi, Surabaya, Fakultas Farmasi Universitas Surabaya.
Funk JL, 2006, Pathophysiology of Disease: Disorder of The Pancreas-An Introduction to Clinical Medicine, McPhee SJ, Ganong WF (editor) , Lange Medical Book, New York.
Gale EAM, Anderson JV, 2004, Clinical Medicine 5th ed: Diabetes Mellitus an Other Disorder of Metabolism., Kumar P, Clark M (editor), WB Saunders, Edinburgh.
Ganong William F, 2001, Review of Medical Physiology: Human Physiology, McGraw-Hill, New York.
Gondokesumo Marisca Evalina, 2010, Efek Ekstrak Bawang Sabrang (Eleutherine americana Merr.) Terhadap Tikus Putih Jantan (Rattus norvegicus) Diabetes Mellitus Tipe 1, Skripsi, Surabaya, Fakultas Farmasi Universitas Surabaya.
Herbarium Bandungense, 2010, Klasifikasi Jambu Biji, (online)
(http://www.bi.itb.ac.id/herbarium/index.php?c=herbs&view=detail&spid=207885)
Holland O B, Kuhnert L von, Campbell W B et al, Synergistic Effect of Captopril With Hydrochlorothiazide for The Treatment of Low-renin Hypertensive Black Patiens, 1983, American Heart Assosiation, 5: 235-239, (online)
(http://hyper.ahajournal.org diakses pada 5 Oktober 2012).
Jordan Ahmad, 2010, Aneka Buah dan Khasiatnya, Aulia Publishing, Kyapyak, Sleman.
Katzung BG, Trevor AJ, 2005, Pharmacology: Examination an Broad Review, 7th ed., Lange Medical Book, New York.
Katzung BG, Trevor AJ, 2007, Basic and Clinical Pharmacology, 10th ed, The McGraw-Hill Companies. Inc.
Lucie Widowati, B Dzulkarnain, Sa’roni, 1997, Tanaman Obat Untuk Diabetes Mellitus,
Cermin Dunia Kedokteran, No 116: 53-60 (online) (http://isjd.pdii.lipi.go.id diases pada 5 Juli 2012).
Marounek et al, 2006, Physiologycal Research, Effect of Pectin and Amidated Pectin on Cholesterol Diet, Institute of Phisiology , V.V.I, Academy of Sciences of The Czech Republic, Prague, Czech republic, http://www.biomedca,cz.
McEvoy GK, Snow EK, Kester L, Welsh Oh, 2008, AHFS Drug Information, The McGraw-Hill Companies, Inc., New York, 2781-2784.
Moningkey, S.I., 2000, Epidemiologi Diabetes Melitus dan Pengendaliannya, Jurnal Kedokteran dan Farmasi Medika.
Neal MJ, 2006, Medical Pharmacology at a Glance, 5th ed, Graphicraft Ltd, Hongkong.
Novayanthi Ni Made Indra, 2009, Efektivitas Kombinasi Rebusan Daun Sirih Merah (Piper crocatum Ruiz & Pav.) dan Biji Mahoni (Swie macrophylla King) Terhadap Kadar Glukosa Darah Tikus Putih Jantan Hiperglikemia, Skripsi, Universitas Surabaya, Surabaya.
Reid L John, Rubin Peter C, Komala Sugiat0, 2008, Lecture Notes On Clinical Pharmacology, EGC, Jakarta.
Rengjui Sirirat, Roncal Carlos A, Mu Wei et al, 2007, Thiazide Diuretics Exacerbate Fructose-Induced Metabolic Syndrome, (online), (http://www.jasn.org diakses pada 21 September 2012).
Published
2013-09-20
Section
Bidang Farmasi (F)
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