ANALISIS HIDROKUINON SECARA SPEKTROFOTOMETRI SINAR TAMPAK DALAM SEDIAAN KRIM MALAM NC-16 DAN NC-74 DARI KLINIK KECANTIKAN LSC SURABAYA
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Keywords:
hidrokuinon, spektrofotometer sinar tampak, krim malam
Abstract
Telah dilakukan penelitian terhadap sampel krim malam NC-16 dan NC-74 dari Klinik Kecantikan LSC Surabaya. Hasil uji kualitatif yang dilakukan dengan reaksi warna dengan menggunakan Benedict’s Reagent dan Ferri Chloride, dan secara kromatografi lapis tipis (KLT) terhadap 2 sampel didapatkan data bahwa sampel krim malam NC-16 mengandung hidrokuinon dan NC-74 tidak mengandung hidrokuinon. Pada penelitian ini juga dilakukan uji kuantitatif secara spektrofotometri sinar tampak dengan menggunakan pereaksi floroglusinol yang didahului dengan validasi metode dan didapatkan hasil persen perolehan kembali berturut-turut adalah 104,73%; 98,87% dan 99,57% , KV = 0,47% dan hasil tersebut memenuhi persyaratan validasi metode analisis. Pada penetapan kadar didapatkan kadar hidrokuinon dalam sediaan krim malam NC-16 = 3,71% dan sediaan NC-74 tidak terdapat adanya hidrokuinon.
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Charlín R, Barcaui CB, Bernard Kawa Kac BK, Soares DB, Fonseca RR, Abulafia LA, 2008, Hydroquinone-Induced Exogenous Ochronosis: A Report Of Four Cases And Usefulness Of Dermoscopy, International Journal of Dermatology, Vol. 47, 19–23.
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Deinstrop EH, 2007, Applied Thin-Layer Chromatographyc, 2nd editions, Published by WILEY-VCH Verlag GmbH & Co. KGaA,Weinheim: German.
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Ermer J dan Miller JHMcB, 2005, Method Validation in Pharmaceutical Analysis A Guide to Best Practice, John Wiley & Sons Ltd,England, 200-212.
Gandjar IG, Rohman A, 2007, Kimia Farmasi Analisis, Pustaka Pelajar, Yogyakarta.
Published
2014-03-01
Section
Bidang Farmasi (F)
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