STABILITAS FISIKA SEDIAAN BODY SCRUB MENGANDUNG BEKATUL, RICE BRAN OIL, VIRGIN COCONUT OIL (VCO), KOPI DAN EKSTRAK ALOE VERA DENGAN BAHAN PENGAWET DMDM HYDANTOIN DAN NATRIUM BENZOAT

  • Betty Amalliyah Fakultas Farmasi Universitas Surabaya
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Keywords: Rice Bran, Rice Bran Oil, Virgin Coconut Oil, Coffee, Aloe Vera Extract, DMDM Hydantoin

Abstract

Stability studies have been conducted physical body scrub cream preparation containing an active ingredient Bran, Rice Bran Oil, Telah dilakukan penelitian stabilitas fisika sediaan krim body scrub yang mengandung bahan aktif Bekatul, Rice Bran oil, Virgin coconut oil (VCO), Kopi, dan Ekstrak Aloe Vera. Dilakukan perbandingan stabilitas fisika terhadap dua formula berbeda. Formula I mengandung Bekatul 4%, Rice Bran oil 3%, VCO 2%, Kopi 4%, Ekstrak Aloe Vera 5% dengan tambahan pengawet DMDM Hydantoin (Dimethylol-5,5-dimethyl hydantoin) 0,5%. Formula II mengandung Bekatul 4%, Rice Bran Oil 3% VCO 2%, Kopi 4%, Ekstrak Aloe Vera 5% dengan tambahan pengawet Na Benzoat 0,5%. Sediaan disimpan dalam alat climatic chamber suhu 40ºC ± 2ºC / 75% RH ± 5% selama 30 hari. Pengamatan stabilitas fisika dilakukan pada hari ke-0, 15, dan 30 dan dilakukan parameter uji stabilitas meliputi organoleptis, viskositas, sifat alir, berat jenis, ukuran droplet dan pH. Hasil penelitian menunjukkan untuk formula I tidak stabil dalam hal organoleptis yaitu terdapat perubahan warna dan terdapat jamur hari ke-30, selain itu dalam hal berat jenis, pH. Formula II stabil dalam hal orgnoleptis dan viskositas, yang ditunjukkan dengan tidak ada perubahan warna dan tidak terdapat jamur.

Virgin Coconut Oil (VCO), Coffee, and Aloe Vera Extract. Do a comparison of the physical stability of two different formulas. Formula I contains bran 4%, 3% Rice Bran oil, VCO 2%, 4% coffee, Aloe Vera Extract with 5% additional preservatives DMDM Hydantoin (Dimethylol-5,5-dimethyl hydantoin) 0.5%. Formula II contains 4% Bran, Rice Bran Oil VCO 2% 3%, 4% coffee, Aloe Vera Extract with 5% Na Benzoate preservatives added 0.5%. The preparation is stored in a climatic chamber device temperature of 40 º C ± 2 º C / 75% RH ± 5% for 30 days. Physical stability observations performed on days 0, 15, and 30 and performed include organoleptic test parameter stability, viscosity, flow properties, density, droplet size and pH. The results showed for the first formula is not stable in terms of organoleptic that there are fungal discoloration and day 30, as well as in terms of specific gravity, pH. Formula II is stable in terms of orgnoleptis and viscosity, as indicated by no color change and there is no fungal

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References

Agoes G, 2008, Seri Farmasi Industri-1: Pengembangan Sediaan Farmasi, Edisi Revisi dan Perluasan, Penerbit ITB, Bandung, 31, 121-128, 174-179.

Akhtar N, 2011, Formulation Development and Moiturising Effects of a Topical Cream of Aloe vera Extract, World Academy of Science, Engineering and Technology 51.

ASEAN Guideline, 2005, ASEAN Guideline on Stability Study of Drug Product, ASEAN Consultative Committee for Standart and Quality, Philippines.

Badan POM Republik Indonesia, 2010, Petunjuk Operasional Pedoman Cara Pembuatan Kosmetik yang Baik, Jakarta.

Barel OA, Paye M, Maibach HI, 2001, Handbook of Cosmetic Science and Technology, Marcel Dekker Inc., New York, 53-64.

Bernardi et al, 2011, Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments, Journal of Nanobiotechnology 2011, 9:44 Brazil.

Departemen Kesehatan Republik Indonesia, 1995, Farmakope Indonesia, Edisi IV, Departemen Kesehatan, Jakarta.

Djajadisastra J, 2004, Cosmetic Stability, Makalah disajikan dalam Seminar Setengah Hari HIKI, Jakarta, 18 November

Lachman L, Lieberman HA, Kanig JL, 1994, Teori dan Praktek Farmasi Industri, Jilid II, Edisi II, Universitas Indonesia Press, Jakarta 1077, 1080.

Liebert MA, 1988, Final Report on the Safety Assessment of DMDM Hydantoin, Journal of American collage of toxicology Volume 7 Number 3.

Mansor TST, Che Man YB, et al., 2012, Physicochemical Properties of Virgin Coconut oil Extracted from Different Processing Methods, International Food Research Journal Vol. 19(3): 837-845.

Marina, A. M., Che Man, Y. B., & Amin, I. (2009). Virgin coconut oil: emerging functional food oil, Trends in Food Science & Technology 20 (2009) 481-487.

Martin A, Swarbrick J, Cammarata A, 1983, Farmasi Fisik: Dasar-Dasar Kimia Fisik dalam Ilmu Farmasetik, edisi ketiga Jilid 2, Terjemahan oleh Yoshita, 1993, UI-Press, Jakarta, 1143-1183.

Michalun N, Varinia M, 2010, Millady’s Skin Care & Cosmetic Ingredients Dictionary 3rd edition, Erin O’Connor, USA, 11-21.

National Health Surveillance Agency, 2005, Cosmetic Product Stability Guide, National Health Surveillance Agency Press, Brazil.
Published
2014-03-01