STABILITAS FISIKA SEDIAAN BODY SCRUBDENGAN DAN TANPA BAHAN PENGEMULSI DECYL GLUCOSIDE DAN KOMBINASI CETEARYL ALKOHOL DAN CETEARYL GLUCOSIDE SERTA PENAMBAHAN XANTHAN GUM
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Keywords:
Bekatul, ekstrak Licorice, Rice bran oil, Virgin coconut oil, body scrub, stabilitas fisika
Abstract
Telah dilakukan penelitian stabilitas fisika sediaan body scrub yang mengandung bekatul, ekstrak Licorice, rice bran oil, dan virgin coconut oil. Dilakukan perbandingan stabilitas fisika terhadap dua formula berbeda. Formula I mengandung bekatul 4%, rice bran oil 3%, virgin coconut oil 2% dan ekstrak Licorice 2% dengan bahan penstabil emulsi kombinasi cetearyl alcohol dan cetearyl glucoside. Formula II mengandung bekatul 4%, rice bran oil 3%, virgin coconut oil 2% dan ekstrak Licorice 2% dengan bahan penstabil emulsi decyl glucoside serta penambahan xantan gum Sediaan disimpan dalam alat climatic chamber suhu 40ºC 20C / 75% RH 5% selama 30 hari. Pengamatan stabilitas fisika dilakukan pada hari ke-0, 15, dan 30. Parameter yang diamati berupa organoleptis, viskositas, sifat alir, tipe emulsi, berat jenis, ukuran droplet, dan perubahan pH. Hasil penelitian menunjukkan kedua formula stabil dalam, sifat alir, tipe emulsi, berat jenis dan ukuran droplet. Pada Formula I menunjukkan hasil yang tidak stabil dalam hal organoleptis, viskositas dan pH. Sedangkan Formula II menunjukkan hasil yang tidak stabil dalam hal viskositas dan pH.
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ASEAN Guideline, 2005, ASEAN Guideline on Stability Study of Drug Product,
ASEAN Consultative Committee for Standart and Quality, Philippines.
Badan POM Republik Indonesia, 2010, Petunjuk Operasional Pedoman Cara Pembuatan Kosmetik yang Baik, Jakarta.
Barel OA, Paye M, Maibach HI, 2001, Handbook of Cosmetic Science and Technology, Marcel Dekker Inc., New York, 53-64.
Bernardi et al, 2011, Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments, Journal of Nanobiotechnology 2011, 9:44 Brazil.
Chair et al, 2011, Final Safety Assessment Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics, Cosmetic Ingredient Review Expert Panel, Washington DC.
Cognis, 2004, Care chemicals Plantacare®2000UP, Cognis, Swedish.
Da’I, M 2012, Uji Aktivitas Antiradikal Ekstrak Etanol Daun Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, dan Gynura procumbens Merr. Dengan Metode DPPH (1,1-Difenil-2-Pikril Hidrazil) Serta Penetapan Kadar Fenoliknya. PHARMACON , 13 (12), 41-46.
Departemen Kesehatan Republik Indonesia, 1995, Farmakope Indonesia, Edisi IV, Departemen Kesehatan, Jakarta.
Djajadisastra J, 2004, Cosmetic Stability, Makalah disajikan dalam Seminar Setengah Hari HIKI, Jakarta, 18 November
Hardman, R. (Ed.). (2010). Traditional Herbal Medicines for Modern Times. Taylor and Francis Group, LLC.
Lachman L, Lieberman HA, Kanig JL, 1994, Teori dan Praktek Farmasi Industri, Jilid II, Edisi II, Universitas Indonesia Press, Jakarta 1077, 1080.
Liebert MA, 1988, Final Report on the Safety Assessment of DMDM Hydantoin, Journal of American collage of toxicology Volume 7 Number 3.
Mansor TST, Che Man YB, et al., 2012, Physicochemical Properties of Virgin Coconut oil Extracted from Different Processing Methods, International Food Research Journal Vol. 19(3): 837-845.
Marina, A. M., Che Man, Y. B., & Amin, I. (2009). Virgin coconut oil: emerging functional food oil, Trends in Food Science & Technology 20 (2009) 481-487.
Martin A, Swarbrick J, Cammarata A, 1983, Farmasi Fisik: Dasar-Dasar Kimia Fisik dalam Ilmu Farmasetik, edisi ketiga Jilid 2, Terjemahan oleh Yoshita, 1993, UI-Press, Jakarta, 1143-1183.
Michalun N, Varinia M, 2010, Millady’s Skin Care & Cosmetic Ingredients Dictionary 3rd edition, Erin O’Connor, USA, 11-21.
Mitsui T, 1997, New Cosmetic Science, Elsevier Science B. V, Amsterdam.
National Health Surveillance Agency, 2005, Cosmetic Product Stability Guide, National Health Surveillance Agency Press, Brazil.
Parvez S, Kang M, Chung HS, et al., 2006, Survey and Mechanism of Skin Depigmenting and Lightening Agent, Phytotherapy Research Vol. 20:921-934.
Patel M and Naik SN, 2004, Gamma oryzanol from rice bran oil, Journal of Scientific & Industrial research Vol.63 pp 569-578 New Delhi.
Prasad et al, 2011, Health Benefits of Rice Bran, J Nutr Food Sci 2011, 1:3 India.
Rendon, M. I., & Gaviria, J. I., 2005, Skin Lightening In Cosmeceutical (procedures in cosmetic dermatology) (p. 107). Chicago: Elsevier Inc.
Rowe, Raymond C dan Paul J. Sheskey, 2009, Handbook of Pharmaceutical Excipients, 5thedition., Pharmaceutical Press, London.
Saxena S, 2005, Glycyrrhiza glabra: Medicine Over the Millenium, Thapar Institute of Engineering and technology, Punjab, India.
Seppic, 2005, MontanovTM 68: An Emulsifier in Harmony with Nature, SEPPIC France.
Sinko PJ, 2006, Martin’s Physical Pharmacy and Pharmaceutical Science, 5th edition, Lippincott Williams and Wilkins, USA 509-517, 564-565, 574-576, 534, 540-542.
Tabor A, Blair R, 2009, Nutritional Cosmetics Beauty from Within, Elsevier Inc., USA.
Thornfeldt, C. R., & Bourne, K. (2010). New Ideal in Skin Health: Separating Fact from Fiction. Wissenschaftliche.
Tranggono RI, Latifah F, 2007, Buku Pegangan Ilmu Kosmetik Medik, Gramedia Pustaka Utama, Jakarta.
Wasitaatmadja SM, 1997, Penuntun Ilmu Kosmetik Medik, UI-Press, Jakarta.
Winfield AJ, Richards RME, 1998, Pharmaceutical Practice 2nd edition, Churchill Livings.
Published
2013-09-20
Section
Bidang Farmasi (F)
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