Diabetes Melitus dan Antioksidan

  • Dita Sukmaya Prawitasari Fakultas Kedokteran, Universitas Surabaya

Abstract

Abstract — Diabetes mellitus is widely known as one of the non-transmittable diseases which is a global problem because its incidence is increasing every year throughout the world. The condition of hyperglycemia in diabetes mellitus has a very influential effect on endothelial blood vessels due to the process of glucose auto-oxidation in forming free radicals which in turn will produce macro and microvascular dysfunction. Next, this condition will further increase morbidity and mortality rates in people with diabetes mellitus. The using of antioxidants in patients with diabetes mellitus was found to be effective in reducing the emergence of arising complications. This is supported by various the benefits of antioxidants related to pathological process of diabetes mellitus due to conditions of oxidative stress. In the future, the safety and effectiveness of supplements or food contain antioxidants in an effort to overcome the condition of diabetes must still be proven further.


Abstrak— Diabetes melitus banyak dikenal sebagai salah satu penyakit tidak menular yang menjadi masalah global karena insidensinya setiap tahun yang terus meningkat di seluruh dunia. Kondisi hiperglikemia pada diabetes melitus mempunyai efek yang sangat berpengaruh pada endotel pembuluh darah akibat adanya proses auto-oksidasi glukosa dalam membentuk radikal bebas yang pada akhirnya akan menghasilkan disfungsi makro dan mikrovaskular. Kondisi inilah yang selanjutnya akan menimbulkan komplikasi yang selanjutnya akan meningkatkan angka morbiditas maupun mortalitas pada penderita diabetes melitus. Penggunaan antioksidan pada penderita diabetes melitus ternyata diketahui efektif dalam mengurangi munculnya komplikasi yang timbul. Hal ini didukung dengan berbagai penelitian yang membuktikan manfaat antioksidan terkait proses patologi dari diabetes mellitus akibat kondisi stres oksidatif. Pada masa yang akan datang, keamanan dan keefektifan suplemen atau makanan yang mengandung antioksidan dalam upaya mengatasi kondisi diabetes tetap harus dibuktikan lebih lanjut.

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Published
2019-12-17
How to Cite
PRAWITASARI, Dita Sukmaya. Diabetes Melitus dan Antioksidan. KELUWIH: Jurnal Kesehatan dan Kedokteran, [S.l.], v. 1, n. 1, p. 48-52, dec. 2019. ISSN 2715-6419. Available at: <https://journal.ubaya.ac.id/index.php/kesdok/article/view/2496>. Date accessed: 03 july 2020. doi: https://doi.org/10.24123/kesdok.V1i1.2496.