Diabetes Melitus dan Antioksidan

  • Dita Sukmaya Prawitasari Fakultas Kedokteran, Universitas Surabaya
DOI: https://doi.org/10.24123/kesdok.V1i1.2496
Abstract Views: 2984 times
PDF Downloads: 8955 times
Keywords: antioksidan, diabetes melitus, stres oksidatif, antioxidant, oxidative stress

Abstract

Abstract — Diabetes mellitus is widely known as one of the non-transmittable diseases which is a global problem because its incidence is increasing every year throughout the world. The condition of hyperglycemia in diabetes mellitus has a very influential effect on endothelial blood vessels due to the process of glucose auto-oxidation in forming free radicals which in turn will produce macro and microvascular dysfunction. Next, this condition will further increase morbidity and mortality rates in people with diabetes mellitus. The using of antioxidants in patients with diabetes mellitus was found to be effective in reducing the emergence of arising complications. This is supported by various the benefits of antioxidants related to pathological process of diabetes mellitus due to conditions of oxidative stress. In the future, the safety and effectiveness of supplements or food contain antioxidants in an effort to overcome the condition of diabetes must still be proven further.

Abstrak— Diabetes melitus banyak dikenal sebagai salah satu penyakit tidak menular yang menjadi masalah global karena insidensinya setiap tahun yang terus meningkat di seluruh dunia. Kondisi hiperglikemia pada diabetes melitus mempunyai efek yang sangat berpengaruh pada endotel pembuluh darah akibat adanya proses auto-oksidasi glukosa dalam membentuk radikal bebas yang pada akhirnya akan menghasilkan disfungsi makro dan mikrovaskular. Kondisi inilah yang selanjutnya akan menimbulkan komplikasi yang selanjutnya akan meningkatkan angka morbiditas maupun mortalitas pada penderita diabetes melitus. Penggunaan antioksidan pada penderita diabetes melitus ternyata diketahui efektif dalam mengurangi munculnya komplikasi yang timbul. Hal ini didukung dengan berbagai penelitian yang membuktikan manfaat antioksidan terkait proses patologi dari diabetes mellitus akibat kondisi stres oksidatif. Pada masa yang akan datang, keamanan dan keefektifan suplemen atau makanan yang mengandung antioksidan dalam upaya mengatasi kondisi diabetes tetap harus dibuktikan lebih lanjut.

Downloads

Download data is not yet available.

References


  1. Bajaj S. and Khan A. Antioxidant and diabetes. Indian Journal of Endocrinology and Metabolism. 2012;16(2): 267-271a


  2. Basha B., Samuel SM., Triggle CR. And Ding H. Endothelial Dysfunction in Diabetes Mellitus: Possible Involvement of Endoplasmic Reticulum Stress?. Experimental Diabetes Reasearch. 2012: 1-14


  3. Baynest HW. Classification, Pathophysiology, Diagnosis and Management Diabetes Mellitus. Journal of Diabetes & Metabolis. 2015; 6(5)


  4. Ceriello A and Testa R. Antioxidant Anti-Inflammatory Treatment in Type 2 Diabetes. Diabetes Care. 2009;32(2): 5232-5236


  5. Hamilton SJ, Chew GT & Watts GF. Therapeutic regulation of endothelial dysfunction in type 2 diabetes mellitus. Diabetes Vasc Dis Res. 2007;4(2):89-102


  6. Hamilton SJ, Watts GF.Endothelial Dysfunction in Diabetes: Pathogenesis, Significance, and Treatment. The Review of Diabetic Studies. 2013;10(2-3):133-156


  7. Holt RIG, Cockram C, Flyvbjerg A & Goldstein BJ. Textbook of Diabetes, 4th Edition, Wiley-Blackwell, UK. 2010:160-207


  8. Oyenihi AB, Ayeleso AO, Mukwevho E & Masola B. Antioxidant strategies in the management of diabetic neuropathy. BioMed Research International. 2015.


  9. Ozougwu, JC., Obimba KC., Belonwu CD and Unakalamba CB. The Pathogenesis and Pathophysiology of type 1 and type 2 Diabetes Mellitus. Journal of Physiology and Pathophysiology. 2013;4(4): 46-57


  10. Rambhade S., Chakraborty Ak., Patil UK., and Rambhade A. Diabetes Mellitus- Its complications, factors influencing complications and prevention- An Overview. Journal of Chemical and Pharmaceutical Research.2010;2(6): 7-25


  11. Veerabhadra GGK., Rahman MA. And Sudha Patil. 2016. A Study on Antioxidants status in Type 2 Diabetes Mellitus Patients. International Journal of Biomedical and Advance Research; 7(6): 278-280


  12. Zieger.D, Sohr CGH and Zadeh JN. Oxidative Stress and Antioxidant Defense in Relation to the Severity of Diabetic Polyneuropathy and Cardiovascular Autonomic Neuropathy. Diabetes Care.2004;27(9): 2178-2183


Published
2019-12-17
How to Cite
Prawitasari, D. S. (2019). Diabetes Melitus dan Antioksidan. Keluwih: Jurnal Kesehatan Dan Kedokteran, 1(1), 47-51. https://doi.org/10.24123/kesdok.V1i1.2496
Issue
Vol. 1 No. 1 (2019): Keluwih: Jurnal Kesehatan dan Kedokteran (December)
Section
Article Review
Copyright (c) 2019 Dita Sukmaya Prawitasari Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

  • Articles published in Keluwih: JKK are licensed under a Creative Commons Attribution-ShareAlike 4.0 International license. You are free to copy, transform, or redistribute articles for any lawful purpose in any medium, provided you give appropriate credit to the original author(s) and the journal, link to the license, indicate if changes were made, and redistribute any derivative work under the same license.
  • Copyright on articles is retained by the respective author(s), without restrictions. A non-exclusive license is granted to Kluwih: JKK to publish the article and identify itself as its original publisher, along with the commercial right to include the article in a hardcopy issue for sale to libraries and individuals.
  • By publishing in Keluwih: JKK, authors grant any third party the right to use their article to the extent provided by the Creative Commons Attribution-ShareAlike 4.0 International license.