Penyakit Jantung Koroner dan Antioksidan

  • Winnie Nirmala Santosa Fakultas Kedokteran Universitas Surabaya
  • Baharuddin Baharuddin Fakultas Kedokteran Universitas Surabaya
DOI: https://doi.org/10.24123/kesdok.V1i2.2566
Abstract Views: 22187 times
PDF Downloads: 18865 times
Keywords: antioxidant, penyakit jantung coroner, stress oksidatif, coronary heart diseas, oxidative stress

Abstract

Abstract—Coronary heart disease (CHD), one of cardiac diseases, is caused mainly due to the narrowing of the coronary arteries because of atherosclerosis or spasm or a combination of both. Coronary heart disease is one disease that is scary and is still a problem in both the developed and developing countries. The oxidative stress originates mainly in mitochondria from reactive oxygen and reactive nitrogen species (ROS/RNS) and can be identified in most of the key steps in the pathophysiology of atherosclerosis and the consequential clinical manifestations of cardiovascular disease. Treatment of coronary heart disease is by pharmacological treatment and non-pharmacological therapy. One way of non-pharmacological therapy is to eat antioxidant. Several studies have shown that eating antioxidant can reduce LDL oxidation and play a role in inhibiting the process of hardening of the arteries.

Keywords: antioxidant, coronary heart diseas, oxidative stress

Abstrak—Penyakit jantung koroner (PJK) merupakan salah satu penyakit jantung mematikan. Penyebab utama terjadinya penyakit ini adalah penyempitan arteri koronaria. Penyempitan terjadi karena adanya kondisi aterosklerosis atau spasme maupun kombinasi dari keduanya. Penyakit jantung koroner masih menjadi masalah utama baik di negara maju maupun negara berkembang. Kejadian ini dipicu oleh stres oksidatif terutama di mitokondria. Adanya oksigen reaktif dan spesies nitrogen reaktif (ROS / RNS) dan dapat diidentifikasi dalam sebagian besar merupakan kunci dalam patofisiologi aterosklerosis dan manifestasi klinis konsekuensial dari penyakit kardiovaskular. Pengobatan penyakit jantung koroner adalah dengan pengobatan farmakologis dan terapi non-farmakologis. Salah satu cara terapi non-farmakologis adalah dengan mengkonsumsi antioksidan. Beberapa penelitian telah menunjukkan bahwa penggunaan antioksidan dapat mengurangi oksidasi LDL dan menghambat proses pengerasan pembuluh darah.

Kata kunci: antioksidan, penyakit jantung coroner, stress oksidatif

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Published
2020-06-24
How to Cite
Santosa, W. N., & Baharuddin, B. (2020). Penyakit Jantung Koroner dan Antioksidan. Keluwih: Jurnal Kesehatan Dan Kedokteran, 1(2), 95-100. https://doi.org/10.24123/kesdok.V1i2.2566
Issue
Vol. 1 No. 2 (2020): Keluwih: Jurnal Kesehatan dan Kedokteran (June)
Section
Article Review
Copyright (c) 2020 Winnie Nirmala Santosa, Baharuddin Baharuddin (Author) Creative Commons License

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