Studi Literatur tentang Kuantitatif Penggunaan Antibiotik pada Bangsal Bedah dengan DDD

  • Ervin Colyn Fakultas Farmasi, Universitas Surabaya, Jl. Raya Kalirungkut, Surabaya, 60293, Indonesia
  • Fauna Herawati Fakultas Farmasi, Universitas Surabaya, Jl. Raya Kalirungkut, Surabaya, 60293, Indonesia
  • Rika Yulia Fakultas Farmasi, Universitas Surabaya, Jl. Raya Kalirungkut, Surabaya, 60293, Indonesia
DOI: https://doi.org/10.24123/kesdok.V2i1.2975
Abstract Views: 1053 times
PDF Downloads: 1016 times
Keywords: Defined Daily Dose, antibiotik profilaksis, bangsal bedah, Asia, antibiotic prophylaxis, surgery

Abstract

Abstract— Antibiotic resistance is one of the healthcare problems associated with higher medical costs, prolonged hospital stays, and increased mortality rate. Monitoring antibiotic usage purposed to control the incidence of antibiotic resistance. Past research reported that there was an irrational use of surgical prophylaxis in Asia. The objective of this research is to review surgical prophylaxis utilization using DDD method with DDD/100 Bed Days as outcome. The study design used is systematic review. The articles included in this study were cross-sectional study design, in Indonesian or English language, and published between the years 2010-2020. The defined daily dose, antibiotic prophylaxis, surgery were the search term. This study assesses the quality of journals by The Joanna Briggs Institute (JBI) checklist and the journal's reputation. There were eleven articles, five articles had a good quality according to JBI checklist and published at journal indexed Scopus or accredited by National Journal Accreditation (ARJUNA) SINTA 1-3. The most used surgical prophylaxis antibiotic in 6 locations was ceftriaxone. Meanwhile, Cefazolin, the first choice surgical prophylaxis antibiotic recommended by the guideline, only reported being used the most at 2 locations. In Asia, there are irrational surgical prophylaxis antibiotic utilizations. The monitoring of surgical prophylaxis antibiotic use needs to be improved to increase the appropriateness.
Keywords: Defined Daily Dose, antibiotic prophylaxis, surgery, Asia

Abstrak—Resistensi antibiotik merupakan salah satu masalah kesehatan karena meningkatkan biaya perawatan, memperpanjang lama rawat di rumah sakit, dan meningkatkan angka kematian. Pemantauan penggunaan antibiotik bertujuan untuk mengendalikan kejadian resistensi antibiotik. Penelitian terdahulu melaporkan bahwa masih banyak terjadi pemakaian antibiotik secara irasional di bangsal bedah di Asia. Penelitian ini bertujuan untuk mengkaji pola pemakaian antibiotik di bangsal bedah dalam satuan DDD/100 bed days. Penelitian ini merupakan kajian sistematik. Artikel terpilih dalam penelitian ini adalah artikel penelitian potong lintkang, berbahasa Indonesia atau Inggris, dan dipublikasi antara tahun 2010 sampai 2020. Kata kunci yang dipakai adalah defined daily dose, antibiotic prophylaxis, surgery. Kualitas jurnal dinilai dengan checklist Joanna Briggs Institute (JBI) dan reputasi jurnal.  Hasil: Didapatkan sebelas artikel, lima jurnal memiliki kualitas baik menurut checklist JBI dan dipublikasi oleh jurnal terindeks Scopus atau terakreditasi Sinta 1-3. Berdasarkan hasil sintesis, antibiotik golongan sefalosporin merupakan antibiotik yang paling sering dipakai. Seftriakson dilaporkan pada 6 lokasi sebagai antibiotik yang paling sering dipakai sebagai profilaksis pembedahan, sedangkan sefazolin, antibiotik pilihan utama yang direkomendasikan oleh pedoman terapi, hanya dilaporkan paling banyak digunakan di 2 lokasi. Di Asia, penggunaan antibiotik profilaksis di bangsal bedah masih ada yang irasional. Pemantauan penggunaan antibiotik profilaksis di bangsal bedah perlu ditingkatkan.
Kata kunci: Defined Daily Dose, antibiotik profilaksis, bangsal bedah, Asia

Downloads

Download data is not yet available.

References

  1. Akalin, S., Kutlu, S. S., Cirak, B., Eskiçorapcı, S. Y., Bagdatli, D., & Akkaya, S. (2012). Application of ATC/DDD methodology to evaluate perioperative antimicrobial prophylaxis. International journal of clinical pharmacy, 34(1), 120-126. https://doi.org/10.1007/s11096-011-9601-3


  2. Aslam, B., Wang, W., Arshad, M. I., Khurshid, M., Muzammil, S., Rasool, M. H., Nisar, M. A., Alvi, R. F., Aslam, M. A., Qamar, M. U., Salamat, M., & Baloch, Z. (2018). Antibiotic resistance: a rundown of a global crisis. Infection and drug resistance, 11, 1645–1658. https://doi.org/10.2147/IDR.S173867


  3. Ayele, Y., & Taye, H. (2018). Antibiotic utilization pattern for surgical site infection prophylaxis at Dil Chora Referral Hospital Surgical Ward, Dire Dawa, Eastern Ethiopia. BMC research notes, 11(1), 537. https://doi.org/10.1186/s13104-018-3629-6


  4. Fazriyah, N. (2017). Evaluasi Penggunaan Antibiotik Profilaksis pada Pasien Bedah Apendektomi dengan Metode ATC/DDD dan DU 90% di Rumah Sakit Umum Daerah Cengkareng Periode Januari-Desember 2016 (Bachelor's thesis, UIN Syarif Hidayatullah Jakarta: Fakultas Kedokteran dan Ilmu Kesehatan, 2017).


  5. Fitriyani, Ramadhan, A. M., & Mahmudah, F. (2018). Studi Penggunaan Antibiotik Berdasarkan ATC/DDD Pada Pasien Bedah Orthopedi Di RSUD Abdul Wahab Sjahranie Samarinda. Proceeding of Mulawarman Pharmaceuticals Conferences, 8(1), 207-213. https://doi.org/10.25026/mpc.v8i1.325


  6. Foroutan, B., & Foroutan, R. (2014). Perioperative antibiotic prophylaxis in elective surgeries in Iran. Medical journal of the Islamic Republic of Iran, 28, 66.


  7. Garcell, H. G., Arias, A. V., Sandoval, C. P., Valle Gamboa, M. E., Sado, A. B., & Alfonso Serrano, R. N. (2017). Impact of a focused antimicrobial stewardship program in adherence to antibiotic prophylaxis and antimicrobial consumption in appendectomies. Journal of infection and public health, 10(4), 415–420.


  8. Harrison, R., Cohen, A. W., & Walton, M. (2015). Patient safety and quality of care in developing countries in Southeast Asia: a systematic literature review. International journal for quality in health care : journal of the International Society for Quality in Health Care, 27(4), 240–254. https://doi.org/10.1093/intqhc/mzv041


  9. Herawati, F., Yulia, R., Hak, E., Hartono, A. H., Michiels, T., Woerdenbag, H. J., & Avanti, C. (2019). A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia. Hospital pharmacy, 54(5), 323–329. https://doi.org/10.1177/0018578718792804


  10. Infectious Diseases Society of America (IDSA), Spellberg, B., Blaser, M., Guidos, R. J., Boucher, H. W., Bradley, J. S., Eisenstein, B. I., Gerding, D., Lynfield, R., Reller, L. B., Rex, J., Schwartz, D., Septimus, E., Tenover, F. C., & Gilbert, D. N. (2011). Combating antimicrobial resistance: policy recommendations to save lives. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 52 Suppl 5(Suppl 5), S397–S428. https://doi.org/10.1093/cid/cir153


  11. Joshi, D. K., Mohd, R., Kothiyal, P., & Joshi, Y. (2017). Evaluation of prescription pattern of antibiotics for surgical prophylaxis in secondary care hospital. Int J Basic Clin Pharmacol, 6, 1969-76.


  12. King, J., & Ciptaningtyas, V. R. (2015). Kuantitas Penggunaan Antibiotik Sebelum Dan Setelah Pembuatan Pedoman Penggunaan Antibiotik (Ppab) Penelitian Pada Kasus Bedah Digestif Rsup Dr. Kariadi Semarang. Jurnal Kedokteran Diponegoro, 4(4), 1072-1082.


  13. Kusuma, A. M., Galistiani, G. F., & Wijayanti, D. N. (2016). Evaluasi Kuantitatif Penggunaan Antibiotik pada Pasien Caesarean Section di RSUD se-Kabupaten Banyumas. Jurnal Farmasi Indonesia Vol, 8(1).


  14. Laras, N. W., & Farida, H. Kuantitas Penggunaan Antibiotik Di Bangsal Bedah Dan Obstetri-ginekologi Rsup Dr. Kariadi Setelah Kampanye Pp-ppra. Jurnal Kedokteran Diponegoro, 1(1), 112516.


  15. Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R, Currie M, Qureshi R, Mattis P, Lisy K, Mu P-F. Chapter 7: Systematic reviews of etiology and risk . In: Aromataris E, Munn Z (Editors). Joanna Briggs Institute Reviewer's Manual. The Joanna Briggs Institute, 2017. Available from https://reviewersmanual.joannabriggs.org


  16. Mousavi, S., Zamani, E., & Bahrami, F. (2017). An Audit of Perioperative Antimicrobial Prophylaxis: Compliance with the International Guidelines. Journal of research in pharmacy practice, 6(2), 126–129. https://doi.org/10.4103/jrpp.JRPP_16_164


  17. Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart L, PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015 Jan 2;349(jan02 1):g7647.


  18. Sözen, H., Gönen, I., Sözen, A., Kutlucan, A., Kalemci, S., & Sahan, M. (2013). Application of ATC/DDD methodology to evaluate of antibiotic use in a general hospital in Turkey. Annals of clinical microbiology and antimicrobials, 12, 23. https://doi.org/10.1186/1476-0711-12-23


  19. Sweileh, W. M., Adas, S. O., Sawalha, A. F., & Taha, A. S. (2012). Utilization and cost of antibacterial drugs in 2 general surgery units in Palestine measured using anatomical therapeutic chemical classification and defined daily dose methodology. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 18(6), 641–647. https://doi.org/10.26719/2012.18.6.641


  20. Thomas, Dixon & Jeewan, A & Alvarez-Uria, Gerardo. (2013). DDDs per hundred bed days of antibiotics used for surgical prophylaxis in a rural resource limited secondary care Indian hospital. Healthcare Interventions Journal. 2013. https://doi.org/10.13140/RG.2.2.21764.88965.


  21. Versporten, A., Zarb, P., Caniaux, I., Gros, M. F., Drapier, N., Miller, M., ... & Hoxha, I. (2018). Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey. The Lancet Global Health, 6(6), e619-e629.


  22. WHO. (2019). The Selection and Use of Essential Medicines. Switzerland: WHO



Published
2020-12-02
How to Cite
Colyn, E., Herawati, F., & Yulia, R. (2020). Studi Literatur tentang Kuantitatif Penggunaan Antibiotik pada Bangsal Bedah dengan DDD. Keluwih: Jurnal Kesehatan Dan Kedokteran, 2(1), 9-22. https://doi.org/10.24123/kesdok.V2i1.2975
Issue
Vol. 2 No. 1 (2020): Keluwih: Jurnal Kesehatan dan Kedokteran (December)
Section
Original Research
Copyright (c) 2020 Ervin Colyn, Fauna Herawati, Rika Yulia Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

  • Articles published in Keluwih: JKK are licensed under a Creative Commons Attribution-ShareAlike 4.0 International license. You are free to copy, transform, or redistribute articles for any lawful purpose in any medium, provided you give appropriate credit to the original author(s) and the journal, link to the license, indicate if changes were made, and redistribute any derivative work under the same license.
  • Copyright on articles is retained by the respective author(s), without restrictions. A non-exclusive license is granted to Kluwih: JKK to publish the article and identify itself as its original publisher, along with the commercial right to include the article in a hardcopy issue for sale to libraries and individuals.
  • By publishing in Keluwih: JKK, authors grant any third party the right to use their article to the extent provided by the Creative Commons Attribution-ShareAlike 4.0 International license.