Peranan Resveratrol terhadap Progresivitas Uterine Fibroid
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Abstract
Abstract--Insulin resistance underlies the pathogenesis of chronic disease, such as diabetes mellitus which has high morbidity and mortality rate. Insulin resistance is a pathological condition when cells fail to respond normally to the insulin hormone, because of insulin signaling pathway disruption. Bound between insulin and insulin’s receptor cannot phosphorylate tyrosine and fail to activate insulin receptor substrate-1 (IRS-1). This failure decrease Glucose transporter-4 (GLUT-4) expression on the skeletal muscle’s cell membrane, that leads to decrease glucose influx and increase blood glucose level. A routine physical training which does according to adequate training dose, will activate adenosin 5’monophosphate-activated protein kinase (AMPK) and lead to the translocation of GLUT-4 vesicles without insulin and insulin’s receptor bonding.GLUT-4 expression on the skeletal muscle’s cell membrane which is stimulated by muscle contraction will increase glucose influx and decrease blood glucose level.
Keywords:insulin resistance; physical training; insulin signaling pathway
Abstrak--Resistensi insulin merupakan penyebab yang mendasari terjadinya penyakit kronis seperti diabetes melitus yang memiliki angka morbiditas dan mortalitas tinggi.Resistensi insulin merupakan keadaan patologis dimana terjadi kegagalan respon seluler terhadap hormon insulin akibat gangguan pada jalur sinyal insulin.Ikatan insulin pada reseptornya tidak dapat menyebabkan fosforilasi tirosin sehingga tidak dapat mengaktivasi insulin receptor substrate-1 (IRS-1). Kegagalan aktivasi tersebut akan menyebabkan penurunan ekspresi Glucose transporter-4 (GLUT-4) pada membran sel otot rangka sehingga ambilan glukosa oleh sel menurun dan glukosa darah meningkat. Latihan fisik yang dilakukan secara rutin, teratur dan sesuai dengan dosis latihan yang tepat dapat mengaktivasi adenosin 5’monophosphate-activated protein kinase (AMPK), sehingga menyebabkan translokasi vesikel berisi GLUT-4, tanpa melalui ikatan insulin dengan reseptornya. Ekspresi GLUT-4 pada membran sel yang dirangsang oleh kontraksi otot akan meningkatkan ambilan glukosa dan menurunkan glukosa darah.
Kata kunci: resistensi insulin; latihan fisik; jalur sinyal insulin
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References
Donnez J, Dolmans M-M. Uterine fibroid management: from the present to the future. Human Reproduction Update. 2016;22(6):665-86.
Stewart EA. Clinical practice. Uterine fibroids. The New England journal of medicine. 2015;372(17):1646-55.
Cardozo ER, Foster R, Karmon AE, Lee AE, Gatune LW, Rueda BR, et al. MicroRNA 21a-5p overexpression impacts mediators of extracellular matrix formation in uterine leiomyoma. Reproductive Biology and Endocrinology. 2018;16(1):1-11.
Pranandari LR, Nugroho H, Aprilawati D. Characteristics of uterine leiomyoma patients at the Department of Obstetrics and Gynecology, Dr. Soetomo Hospital, Surabaya, from January to December 2014. Majalah Obstetri dan Ginekologi. 2017;25(3):81-5.
McWilliams MM, Chennathukuzhi VM, editors. Recent advances in uterine fibroid etiology. Seminars in reproductive medicine; 2017: NIH Public Access.
Khan AT, Shehmar M, Gupta JK. Uterine fibroids: current perspectives. International journal of women's health. 2014;6:95.
Hamoda H, Pepas L, Tasker F, Reidy J, Khalaf Y. Intermediate and long-term outcomes following uterine artery fibroid embolization. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2015;191:33-8.
Burt E, Saridogan E. The Management of Fibroids in Primary Care. Women's Health in Primary Care. 2017:220.
Lee S-c, Liou S-s, Liu I-M, Chang C-r. Herbal composition and a method of treating uterine fibroids. Google Patents; 2015.
Salehi B, Mishra AP, Nigam M, Sener B, Kilic M, Sharifi-Rad M, et al. Resveratrol: A double-edged sword in health benefits. Biomedicines. 2018;6(3):91.
Wu C-H, Shieh T-M, Wei L-H, Cheng T-F, Chen H-Y, Huang T-C, et al. Resveratrol inhibits proliferation of myometrial and leiomyoma cells and decreases extracellular matrix-associated protein expression. Journal of Functional Foods. 2016;23:241-52.
Reis FM, Bloise E, Ortiga-Carvalho TM. Hormones and pathogenesis of uterine fibroids. Best Practice & Research Clinical Obstetrics & Gynaecology. 2016;34:13-24.
Botía C, Camarasa S, Baixauli F, Sanchez A. Uterine fibroids: understanding their origins to better understand their future treatments. J Tumor Res. 2017;3(130):2.
Ciavattini A, Di Giuseppe J, Stortoni P, Montik N, Giannubilo SR, Litta P, et al. Uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction. Obstetrics and gynecology international. 2013;2013.
Tsigkou A, Reis FM, Lee MH, Jiang B, Tosti C, Centini G, et al. Increased progesterone receptor expression in uterine leiomyoma: correlation with age, number of leiomyomas, and clinical symptoms. Fertility and sterility. 2015;104(1):170-5. e1.
Wen S, Zhang J, Yang B, Elias PM, Man M-Q. Role of resveratrol in regulating cutaneous functions. Evidence-Based Complementary and Alternative Medicine. 2020;2020.
Nour V, Trandafir I, Muntean C. Ultraviolet irradiation of trans-resveratrol and HPLC determination of trans-resveratrol and cis-resveratrol in Romanian red wines. Journal of chromatographic science. 2012;50(10):920-7.
Lara-Ochoa F, Sandoval-Minero LC, Espinosa-Pérez G. A new synthesis of resveratrol. Tetrahedron Letters. 2015;56(44):5977-9.
Jeandet P, Chaudruc D, Robillard B, Peters F, Tusseau D, Conreux A, et al. Determination of the trans-resveratrol content of Champagne wines by reversed-phase HPLC. OENO One. 2006;40(2):117-9.
Singh CK, Liu X, Ahmad N. Resveratrol, in its natural combination in whole grape, for health promotion and disease management. Annals of the New York Academy of Sciences. 2015;1348(1):150.
Gokce EH, Korkmaz E, Dellera E, Sandri G, Bonferoni MC, Ozer O. Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications. International journal of nanomedicine. 2012;7:1841.
Shen J, Zhou Q, Li P, Wang Z, Liu S, He C, et al. Update on phytochemistry and pharmacology of naturally occurring resveratrol oligomers. Molecules. 2017;22(12):2050.
Shrotriya S, Tyagi A, Deep G, Orlicky DJ, Wisell J, Wang XJ, et al. Grape seed extract and resveratrol prevent 4‐nitroquinoline 1‐oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses. Molecular carcinogenesis. 2015;54(4):291-300.
Rameshrad M, Imenshahidi M, Razavi BM, Iranshahi M, Hosseinzadeh H. Bisphenol A vascular toxicity: Protective effect of Vitis vinifera (grape) seed extract and resveratrol. Phytotherapy Research. 2018;32(12):2396-407.
Barba FJ, Zhu Z, Koubaa M, Sant'Ana AS, Orlien V. Green alternative methods for the extraction of antioxidant bioactive compounds from winery wastes and by-products: A review. Trends in Food Science & Technology. 2016;49:96-109.
Han G, Xia J, Gao J, Inagaki Y, Tang W, Kokudo N. Anti-tumor effects and cellular mechanisms of resveratrol. Drug discoveries & therapeutics. 2015;9(1):1-12.
Yuan L, Zhang Y, Xia J, Liu B, Zhang Q, Liu J, et al. Resveratrol induces cell cycle arrest via a p53-independent pathway in A549 cells. Molecular medicine reports. 2015;11(4):2459-64.
Chen H-Y, Lin P-H, Shih Y-H, Wang K-L, Hong Y-H, Shieh T-M, et al. Natural antioxidant resveratrol suppresses uterine fibroid cell growth and extracellular matrix formation in vitro and in vivo. Antioxidants. 2019;8(4):99.
Holdsworth-Carson SJ, Zaitseva M, Vollenhoven BJ, Rogers PA. Clonality of smooth muscle and fibroblast cell populations isolated from human fibroid and myometrial tissues. Molecular human reproduction. 2014;20(3):250-9.
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