Penyakit Jantung Koroner dan Antioksidan

  • Winnie Nirmala Santosa Fakultas Kedokteran Universitas Surabaya
  • Baharuddin Baharuddin Fakultas Kedokteran Universitas Surabaya

Abstract

Abstract—Coronary heart disease (CHD), one of cardiac diseases, is caused mainly due to the narrowing of the coronary arteries because of atherosclerosis or spasm or a combination of both. Coronary heart disease is one disease that is scary and is still a problem in both the developed and developing countries. The oxidative stress originates mainly in mitochondria from reactive oxygen and reactive nitrogen species (ROS/RNS) and can be identified in most of the key steps in the pathophysiology of atherosclerosis and the consequential clinical manifestations of cardiovascular disease. Treatment of coronary heart disease is by pharmacological treatment and non-pharmacological therapy. One way of non-pharmacological therapy is to eat antioxidant. Several studies have shown that eating antioxidant can reduce LDL oxidation and play a role in inhibiting the process of hardening of the arteries.


Keywords: antioxidant, coronary heart diseas, oxidative stress


Abstrak—Penyakit jantung koroner (PJK) merupakan salah satu penyakit jantung mematikan. Penyebab utama terjadinya penyakit ini adalah penyempitan arteri koronaria. Penyempitan terjadi karena adanya kondisi aterosklerosis atau spasme maupun kombinasi dari keduanya. Penyakit jantung koroner masih menjadi masalah utama baik di negara maju maupun negara berkembang. Kejadian ini dipicu oleh stres oksidatif terutama di mitokondria. Adanya oksigen reaktif dan spesies nitrogen reaktif (ROS / RNS) dan dapat diidentifikasi dalam sebagian besar merupakan kunci dalam patofisiologi aterosklerosis dan manifestasi klinis konsekuensial dari penyakit kardiovaskular. Pengobatan penyakit jantung koroner adalah dengan pengobatan farmakologis dan terapi non-farmakologis. Salah satu cara terapi non-farmakologis adalah dengan mengkonsumsi antioksidan. Beberapa penelitian telah menunjukkan bahwa penggunaan antioksidan dapat mengurangi oksidasi LDL dan menghambat proses pengerasan pembuluh darah.


Kata kunci: antioksidan, penyakit jantung coroner, stress oksidatif

Downloads

Download data is not yet available.

References


  1. Murray C, Lopez AD. 1997. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 349:1269–76.


  2. World Health Organization; 2006 [diakses tanggal2 April 2016]. Tersedia dari: www.who.int/cardiovascular_diseases/cvd_14_deathHD.pdf


  3. Davidson, C. 2002. Penyakit jantung koroner. Jakarta: PT Dian Rakyat.


  4. World Health Organization. Cardiovascular diseases (CVDs). 2013. Available from:URL:http://www.who.int/mediacentre/factsheets/fs317/en/index.html


  5. Ross R. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:801–809.


  6. Okada, T., Hara, M., E. Saitou, F. Iwata, dan K. Harada. Waist-to-height ratio is the best predictor of cardiovaskular disease risk factor on Japanese children. J. Atheroscler. Thromb. 2007. 9 (3):127-132.


  7. Soeharto I. 2002. Kolesterol dan lemak jahat kolesterol, lemak baik dan proses terjadinya serangan jantung dan stroke. Cetakan kedua. Jakarta: PT Gramedia Pustaka Utama.


  8. Maulana, M. 2008. Penyakit Jantung: Pengertian, Penanganan dan Pengobatan.Yogyakarta: Penerbit Kata Hati.


  9. Anwar TB. 2004. Faktor risiko penyakit jantung koroner. Sumatera Utara: E-USU Repository.


  10. Scalzo J, Politi A, Pellegrini N, Mezzetti B, Battino M. 2005. Plant genotype affects total antioxidant capacity and phenolic contents in fruit. Nutrition. 21(2):207-13.


  11. Baigent C, Keech A, Kearney P, et al. Atherosclerosis[internet]. USA: American Heart Association; 2013 [diakses tanggal 2 April 2016]. Tersedia dari: http://www.heart.org/HEARTORG/Conditions/Cholesterol/WhyCholesterolMatters/Atherosclerosis_UCM_305564_Article.jsp


  12. Benhar M, Engelberg D, Levitski A. 2002. Reactive oxygen species (ROS), stress-activated kinases and stress signaling in cancer. EMBO reports. 3(5):420-5.


  13. Cooper GM, Hausman RE. The cell a molecular approach. Washington: ASM Press; 2003.


  14. Taniyama Y and Griendling KK. Reactive Oxygen Species in the Vasculature:Molecular and Cellular Mechanisms. Hypertension. 2003; 42:1075-1081.


  15. Griendling KK, Sorescu D, Ushio-Fukai M. NADPH oxidase: role in cardiovascular biology and disease. Circ Res 2000;86:494–501.


  16. Landmesser U, Merten R, Spiekermann S, Buttner K, Drexler H, Hornig B. 2000. Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Circulation 101:2264–2270.


  17. Evans JL, Goldfine ID, Maddux BA dan Grdsky GM, 2003. Are Oxidative Stress Activated Signaling Pathways Mediators Of Insulin Resistance And Cell Dysfunction?, Diabetes; vol. 52, no. 1:1-8.


  18. Marciniak A, Brzeszczynska J, Gwozdzinski K, Jegier A, 2009. Antioxidant Capacity and Physical Exercise. Biology of Sport, Vol. 26 No3, 197-213.


  19. Lee IM, 1999. Antioxidant vitamins in the prevention of cancer. Proc Assoc Am Physicians; 111: 10–5.


  20. Frei B, 1999. On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc. Soc. Exp. Biol. Med. 222, 196–204.


  21. Shapiro SS, Saliou C, 2001. Role of vitamins in skin care. Nutrition [homepage on the Internet cited: 2012 Jan 13]. Available from: http://dexa-medica.com.


Published
2020-06-24
How to Cite
SANTOSA, Winnie Nirmala; BAHARUDDIN, Baharuddin. Penyakit Jantung Koroner dan Antioksidan. KELUWIH: Jurnal Kesehatan dan Kedokteran, [S.l.], v. 1, n. 2, p. 98-103, june 2020. ISSN 2715-6419. Available at: <http://journal.ubaya.ac.id/index.php/kesdok/article/view/2566>. Date accessed: 30 oct. 2020. doi: https://doi.org/10.24123/kesdok.V1i2.2566.