Vaksinasi Measles, Mumps, dan Rubella (MMR) Sebagai Prophylaxis Terhadap COVID-19

  • Sajuni Widjaja Fakultas Kedokteran Universitas Surabaya
DOI: https://doi.org/10.24123/kesdok.V1i2.2570
Abstract Views: 2624 times
PDF Downloads: 1182 times
Keywords: SARS-CoV-2, COVID-19, prophylaxis, MMR

Abstract

Abstract-COVID-19 is an infection caused by SARS-CoV-2 and has been declared a pandemic by WHO. At present there is no therapy or vaccine available for handling COVID-19. Data obtained in China, Italy and South Korea show fewer children under 10 years of age are infected with COVID-19, and even if they have an infection they generally experience mild symptoms even without symptoms. Children get routine vaccinations and various infections. This seems to train the immune system of children so that it is more immune to COVID-19. MMR vaccination demonstrates partial preventive protection against COVID-19. This is due to several previous studies that measles vaccine provides protection against pathogens other than measles and also because of the similarity between the protein S in SARS-CoV-2 with protein F in Measles virus (measles) and protein E in Rubella virus (German measles). Prophylaxis is a way to prevent disease. This review will discuss the possibility of giving MMR vaccination as a protection against COVID-19.

Keywords: SARS-CoV-2, COVID-19, prophylaxis, MMR

Abstrak–COVID-19 merupakan infeksi yang dikarenakan SARS-CoV-2 dan telah dinyatakan sebagai pandemi oleh WHO. Saat ini belum didapatkan terapi maupun vaksin dalam menangani COVID-19. Data yang didapat di negara China, Itali dan Korea selatan menunjukkan anak-anak usia di bawah 10 tahun lebih sedikit yang terinfeksi COVID-19, dan kalaupun mengalami infeksi umumnya mengalami gejala ringan bahkan tanpa gejala. Anak-anak mendapatkan rutin vaksinasi dan berbagai infeksi. Hal ini nampaknya melatih sistem imun anak-anak sehingga lebih kebal terhadap COVID-19. Vaksinasi MMR menunjukkan perlindungan pencegahan parsial terhadap COVID-19. Hal ini dikarenakan beberapa penelitian sebelumnya bahwa vaksin campak memberikan perlindungan terhadap pathogen selain campak dan juga karena adanya kesamaan antara protein S SARS-CoV-2 dengan protein F pada virus Measles (campak) dan protein E pada virus Rubella (campak jerman). Profilaksis merupakan cara untuk mencegah penyakit. Review ini akan membahas mengenai kemungkinan pemberian vaksinasi MMR sebagai perlindungan terhadap COVID-19.

Kata kunci: SARS-CoV-2, COVID-19, profilaksis, MMR

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References

  1. Jin Y, Yang H, Ji W, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses. 2020;12(4):372. Published 2020 Mar 27. doi:10.3390/v12040372.


  2. Liu J, Liao X, Qian S, Yuan J, Wang F, Liu Y, et al. Community Transmission of Severe Acute Respitatory Syndrome Coronavirus 2, Shenzhen, China, 2020. Emerg Infect Dis J (Internet) 2020;26(6).


  3. Worldmeter COVID-19 Coronavirus Pandemic. https://www.worldometers.info/coronavirus/? utm_campaign=homeAdvegas1?, diunduh tanggal 20 Juni 2020.


  4. Worldmeter COVID-19 Coronavirus Pandemic. https://www.worldometers.info/coronavirus/country/indonesia/, diunduh tanggal 20 Juni 2020.



  5. Carrozzi G, Sampaolo L, Bolognesi L, Bertozzi N, Ferrante G, Minardi V, et al. Epidemic COVID-19. 2020.


  6. https://www.kompas.com/tren/read/2020/05/23/162900365/viral-idai-ungkap-data-kasus-covid-19-pada-anak-ini-penjelasannya?page=all, diunduh tanggal 20 Juni 2020.


  7. Dhochak N, singhal T, Kabra SK, Lodha R. Pathophysiology of COVID-19: Why Children Fare Better Than Adults? Indian J Pediatrics. 2020.



  8. Steinglass R. Routine immunization: an essential but wobbly platform. Glob Heal Sci Pract. 2013;1(3):295-301.


  9. Salman s, Salem ML. Routine childhood immunization may protect against COVID-19. Medical Hypotheses. 2020.


  10. Baskar PV, Collins GD, Dorsey-Cooper BA, Pyle RS, Nagel JE, Dwyer D, et al. serum antibodies to HIV-1 are produced post-measles virus infection: evidence for cross-reactivity with HLA. Clin Exp Immunol. 1998.


  11. Bermejo-Martin JF, Almansa r, Menendez R, Mendez r, Kelvin DJ, Torres A. Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection. The Journal of Infection. England; 2020.


  12. Sidiq KR, Sabir DK, Ali SM dan Kodzius R. Does Early Childhood Vaccination Protect Against COVID-19? Front. Mol. Biosci. 7:120. 2020.


  13. Sallard E, Lescure FX, Burdet C, Guedj J, Yazdanpanah Y, Smadja NP. Repurposed prophylaxis strategies for COVID-19 : a review. 2020.


  14. Li X, Geng M, Peng Y, Meng L, Lu S. Molecular Immune pathogenesis and diagnosis of COVID-19. Journal of Pharmaceutical Analysis. 2020.


  15. Burkard, c. et al. Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner. PLoS Pathog. 2014.


  16. de Wit E, van Doremalen N, Falzarano D, et al. SARS and MERS: recent insights into emerging coronaviruses. Nat. Rev. Microbiol., 2016, 14: 523-534.



  17. Spiga O, Bernini A, clutti A, Chiellini s, Menciassi N, Finetti F, Causarano V, Anselmi F, Prischi F dan Niccolai. Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein. Biochem. Biophys. Res. Commun. 2003, 310:78.


  18. Saad ME, Elsalamony RA. Measles vaccines may provide partial protection against COVID-19. Int. J Cancer & Biomedical Research. Vol. 5(1): 14-19. 2020.


  19. Walls AC, Tortorici AM, Bosch B, Frenz B, Rottier PJM, DiMaio F, Rey FA dan Veesler D. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature volume, 531:114-7. 2016.


  20. Larsen JEP, Lund O, dan Nielsen M. Improved method for lineal B-cell. Epitopes. Immun Res. 2:2. 2006.


  21. Hamborsky J, Kroger A, Wolfe C. Epidemiology and Prevention of Vaccine-Preventable Diseases 13th Edition. CDC. 2015.


  22. Netea MG, Dominguez J, Barreiro LB, et al. Defining trained immunity and its role in health and disease. Nat Rev Immunol. 2020.


  23. Miller A, Reandelar MJ, Fasciglione K, roumenova V, Li Y, Otazu GH. Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: An epidemiological study. MedRxiv. 2020.


  24. Kleinnijenbuis J, Quintin J, Preijers F, et al. Long-lasting effects of BCG vaccination on both heterologuous Th1/Th17 responses and innate trained immunity. J innate Immun. 2014.


Published
2020-06-24
How to Cite
Widjaja, S. (2020). Vaksinasi Measles, Mumps, dan Rubella (MMR) Sebagai Prophylaxis Terhadap COVID-19. Keluwih: Jurnal Kesehatan Dan Kedokteran, 1(2), 74-77. https://doi.org/10.24123/kesdok.V1i2.2570
Issue
Vol. 1 No. 2 (2020): Keluwih: Jurnal Kesehatan dan Kedokteran (June)
Section
Article Review
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