Deteksi Dini Perlemakan Hati Akut Dalam Kehamilan (Acute fatty liver of pregnancy (AFLP)) dan Penanganannya dengan Diet Rendah Lemak

  • Rachmad Poedyo Armanto Fakultas Kedokteran Universitas Surabaya
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Keywords: AFLP, low fat, high carbohydrate, rendah lemak, tinggi karbohidrat

Abstract

Abstract-Acute fatty liver of pregnancy (AFLP), is a very rare disease. This disease potentially make intra uterine fetal death for the fetus and post partum hemorrhage because of disseminated intravascular coagulation (DIC). But, if we learn the patophysiology of this disease, it could be prevented with early detection and dietary manipulation. Dietary manipulation is low fat diet and high carbohydrate. It will decrease morbidity and mortality of the mother and baby.

Keywords: AFLP, low fat, high carbohydrate

Abstrak-Penyakit perlemakan hati akut dalam kehamilan (Acute fatty liver of pregnancy (AFLP)), adalah gangguan yang jarang terjadi. Penyakit ini berpotensi menimbulkan kefatalan pada janin yaitu berupa kematian janin dalam rahim (IUFD) dan ibu hamil berupa perdarahan paska salin karena gangguan pembekuan darah (DIC). Jika ditelaah dari patofisiologinya, penyakit ini sebenarnya dapat dicegah dengan cara deteksi dini dan penatalaksanaan yang tepat. Penatalaksanaan saat kehamilan adalah dengan melakukan diet rendah lemak, tinggi karbohidrat agar komplikasi pada ibu dan janin tidak terjadi. Sehingga nantinya morbiditas dan mortalitas dapat ditekan serendah mungkin.

Kata kunci: AFLP, rendah lemak, tinggi karbohidrat

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References

  1. Sheehan HL. The pathology of acute yellow atrophy and delayed chloroform poisoning. J Obstet Gynaecol Br Emp. 1940;47:49–62.


  2. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, and Wenstrom KD, 2005. Williams obstetrics: Hepatic, biliary tract, and pancreatic disorders, 22nd Edition. New York: McGraw-Hill Company; pp. 1127-9.


  3. Foley MR, Strong TH, and Garite TJ, 2004.Obstetric intensive care manual, 2nd Edition. New York: McGraw-Hill; pp. 207-15.


  4. Burrow GN, Duffy TP, and Copel JA, 2004. Medical complication during pregnancy: Liver diseases, 6th Edition. Philadelphia: Elsevier Saunders; pp.279-304.


  5. Ibdah JA, Bennet MJ, Rinaldo P, Zhao Y, Gibson B, Sims HF, and Strauss AW, 1999. A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women. N Eng J Med; 340:1723-31.


  6. Moldenhauer JS, O’Brien JM, Barton JR, and Sibai B, 2004. Acute fatty liver of pregnancy associated with pancreatitis: a life-threatening complication. Am J Obstet Gynecol; 190: 502-5.


  7. Maitra A, Saad RD, Yost N, Cunningham G, Rogers BB and Bennet MJ, 2002. Absence of the G1528C(E474Q) mutation in the α-subunit of the mitochondrial trifunctional protein in women with acute fatty liver of pregnancy. Pediatric Research 51:658-661.


  8. Ibdah JA. Acute fatty liver of pregnancy: An update on pathogenesis and clinical implications. World J Gastroenterol. 2006 Dec 14; 12(46): 7397–7404.


  9. Shekhawat P, Bennett MJ, Sadovsky Y, Nelson DM, Rakheja D, Strauss AW. Human placenta metabolizes fatty acids: Implications for fetal fatty acid oxidation disorders and maternal liver diseases. Am J Physiol Endocrinol Metab. 2003;284:E1098–105.


  10. Grimbert S, Fisch C, Deschamps D, et al. Effect of female sex hormones on mitochondria: possible role in acute fatty liver of pregnancy. Am J physiol 1995; 268: G107-15


  11. Innes AM, Seargeant LE, Balachandra K, Roe CR, Wanders RJ, Ruiter JP, Casiro O, Grewar DA, Greenberg CR. Hepatic carnitine palmitoyltransferase I deficiency presenting as maternal illness in pregnancy. Pediatr Res. 2000;47:43–45.


  12. Goel A, Ramakrishna B, Zachariah U, et al. How accurate are the Swansea criteria to diagnose acute fatty liver of pregnancy in predicting hepatic microvesicular steatosis? Gut 2011;60:138-9.


  13. Wang S, Li SL, Cao YX, Li YP, Meng JL, Wang XT. Noninvasive Swansea criteria are valuable alternatives for diagnosing acute fatty liver of pregnancy in a Chinese population. J Matern Fetal Neonatal Med. 2017 Dec;30(24):2951-2955.


  14. Suzuki S, Watanabe S, and Araki T. Acute fatty liver of pregnancy at 23 weeks of gestation. Br J Obstet Gynaecol. 2001 Feb;108: 223-224.


  15. Jwayyed SM, Blanda M, Kubina M. Acute fatty liver of pregnancy. J Emerg Med 1999;17:673-677.


  16. Buytaert IM, ElewautAG, VanKetsHE. Earlyoccurrenceofacutefatty liver in pregnancy. Am J Gastroenterol 1996;91:603-604.


  17. Gillingham M, Calcar SV, Ney D, Wolf J, and Harding C. Dietary management of long-chain 3 hydroxyacyl-CoA dehydrogenase deficiency (LCHADD). A case report and survey. J Inherit Metab dis. 1999 April; 22(2): 123-131.


  18. Nelson DB, Yost NP, Cunningham FG. Acute fatty liver of pregnancy: Clinical outcomes and expected duration of recovery. Am J Obstet Gynecol. 2013;209:456.e1–7.


  19. Yang Z, Yamada J, Zhao Y, Strauss AW, Ibdah JA. Prospective screening for pediatric mitochondrial trifunctional protein defects in pregnancies complicated by liver disease. JAMA. 2002;288:2163–6.


Published
2020-06-24
How to Cite
Armanto, R. P. (2020). Deteksi Dini Perlemakan Hati Akut Dalam Kehamilan (Acute fatty liver of pregnancy (AFLP)) dan Penanganannya dengan Diet Rendah Lemak. Keluwih: Jurnal Kesehatan Dan Kedokteran, 1(2), 78-85. https://doi.org/10.24123/kesdok.V1i2.2593