Anosmia pada COVID-19: Studi Neurobiologi

  • Dwi Martha Nur Aditya Fakultas Kedokteran, Universitas Surabaya, Jl. Raya Kalirungkut, Surabaya, 60293, Indonesia
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Keywords: Covid-19, Anosmia, Neurobiologi

Abstract

Abstract— A few months ago there was Covid-19 virus outbreak by SARS-CoV-19 virus which has clinical manifestations, one of which is Anosmia. Anosmia cause patient was experienced smell’s decreasing which causes psychological problems that loss of comfort and appetite. This condition may also cause imunity’s decreasing in patient. Anosmia in Covid-19 patients could be temporary, if the body's immune system is maintained in good condition, one of the factors is continuing provide healthy and nutritious food intake, even though in tasteless conditions. Therefore, this article can be used as an educational material for the public, how to understand the neurobiological conditions of anosmia in Covid-19, further to avoid depressed due to loss of taste which could be lead to loss appetite.
Keywords: Covid-19, Anosmia, Neurobiology

Abstrak— Beberapa bulan lalu telah terjadi penyebaran wabah virus Covid-19 oleh SARS-CoV-19 virus yang memiliki manifestasi klinis salah satunya adalah Anosmia. Kondisi anosmia menyebabkan kondisi pasien mengalami penurunan daya penciuman yang menyebabkan gangguan psikologis berupa kehilangan rasa nyaman dan kehilangan napsu makan. Kondisi ini sudah barang tentu akan menyebabkan penurunan daya imunitas pasien. Anosmia pada pasien Covid-19 bersifat sementara, apabila daya imunitas tubuh tetap dijaga dalam keadaan baik, salah satu faktornya adalah tetap memberikan asupan makan sehat dan bergizi, meskipun dalam kondisi tasteless. Oleh karena itu, dengan adanya artikel ini dapat digunakan sebagai bahan edukasi kepada khalayak, bagaimana memahami kondisi anosmia pada Covid-19 secara neurobiologi, sehingga dapat menghindarkan rasa depresi karena kehilangan rasa akan makaman yang dapat menyebabkan turunnya napsu makan.
Kata kunci: Covid-19, Anosmia, Neurobiologi

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References

  1. Butowt R, von Bartheld CS. Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection. Neurosci [Internet]. 2020 Sep 11;107385842095690. Available from: http://journals.sagepub.com/doi/10.1177/1073858420956905

  2. Farah Yusuf Mohamud M, Garad Mohamed Y, Mohamed Ali A, Ali Adam B. Loss of Taste and Smell are Common Clinical Characteristics of Patients with COVID-19 in Somalia: A Retrospective Double Centre Study. Infect Drug Resist [Internet]. 2020 Jul;Volume 13:2631–5. Available from: https://www.dovepress.com/loss-of-taste-and-smell-are-common-clinical-characteristics-of-patient-peer-reviewed-article-IDR

  3. Butowt R, Bilinska K. SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection. ACS Chem Neurosci [Internet]. 2020 May 6;11(9):1200–3. Available from: https://pubs.acs.org/doi/10.1021/acschemneuro.0c00172

  4. Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Oto-Rhino-Laryngology [Internet]. 2020 Aug 6;277(8):2251–61. Available from: http://link.springer.com/10.1007/s00405-020-05965-1

  5. Smeets MAM, Veldhuizen MG, Galle S, Gouweloos J, de Haan A-MJA, Vernooij J, et al. Sense of smell disorder and health-related quality of life. Rehabil Psychol [Internet]. 2009 Nov;54(4):404–12. Available from: http://doi.apa.org/getdoi.cfm?doi=10.1037/a0017502

  6. Croy I, Nordin S, Hummel T. Olfactory Disorders and Quality of Life--An Updated Review. Chem Senses [Internet]. 2014 Mar 1;39(3):185–94. Available from: https://academic.oup.com/chemse/article-lookup/doi/10.1093/chemse/bjt072

  7. Crespo C, Liberia T, Blasco-Ibáñez JM, Nácher J, Varea E. Cranial Pair I: The Olfactory Nerve. Anat Rec [Internet]. 2019 Mar;302(3):405–27. Available from: http://doi.wiley.com/10.1002/ar.23816

  8. Pinto JM. Olfaction. Proc Am Thorac Soc [Internet]. 2011 Mar 1;8(1):46–52. Available from: http://pats.atsjournals.org/cgi/doi/10.1513/pats.201005-035RN

  9. Bromley SM. Smell and taste disorders: a primary care approach. Am Fam Physician [Internet]. 2000 Jan 15;61(2):427–36, 438. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10670508

  10. Hatt H. Molecular and Cellular Basis of Human Olfaction. Chem Biodivers [Internet]. 2004 Dec;1(12):1857–69. Available from: http://doi.wiley.com/10.1002/cbdv.200490142

  11. Zwicker D. Normalized Neural Representations of Complex Odors. Matsunami H, editor. PLoS One [Internet]. 2016 Nov 11;11(11):e0166456. Available from: https://dx.plos.org/10.1371/journal.pone.0166456

  12. Boesveldt S, Postma EM, Boak D, Welge-Luessen A, Schöpf V, Mainland JD, et al. Anosmia—A Clinical Review. Chem Senses [Internet]. 2017 Sep 1;42(7):513–23. Available from: https://academic.oup.com/chemse/article/42/7/513/3844730

  13. Dileo MD, Amedee RG. Disorders of taste and smell. J La State Med Soc [Internet]. 1994 Oct;146(10):433–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7798776

  14. Hüttenbrink KB. [Disorders of the sense of smell and taste]. Ther Umsch [Internet]. 1995 Nov;52(11):732–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7502248

  15. Li H, Xue Q, Xu X. Involvement of the Nervous System in SARS-CoV-2 Infection. Neurotox Res [Internet]. 2020 Jun 13;38(1):1–7. Available from: http://link.springer.com/10.1007/s12640-020-00219-8
  16. Berger JR. COVID-19 and the nervous system. J Neurovirol [Internet]. 2020 Apr 23;26(2):143–8. Available from: http://link.springer.com/10.1007/s13365-020-00840-5

  17. Khan S, Gomes J. Neuropathogenesis of SARS-CoV-2 infection. Elife [Internet]. 2020 Jul 30;9. Available from: https://elifesciences.org/articles/59136
Published
2020-12-21
How to Cite
Aditya, D. M. N. (2020). Anosmia pada COVID-19: Studi Neurobiologi. Keluwih: Jurnal Kesehatan Dan Kedokteran, 2(1), 50-55. https://doi.org/10.24123/kesdok.V2i1.3098